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Activin A induces skeletal muscle catabolism via p38β mitogen‐activated protein kinase

BACKGROUND: Activation of type IIB activin receptor (ActRIIB) in skeletal muscle leads to muscle atrophy because of increased muscle protein degradation. However, the intracellular signalling mechanism that mediates ActRIIB‐activated muscle catabolism is poorly defined. METHODS: We investigated the...

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Detalles Bibliográficos
Autores principales: Ding, Hui, Zhang, Guohua, Sin, Ka Wai Thomas, Liu, Zhelong, Lin, Ren‐Kuo, Li, Min, Li, Yi‐Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377410/
https://www.ncbi.nlm.nih.gov/pubmed/27897407
http://dx.doi.org/10.1002/jcsm.12145