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Lipid modulation of skeletal muscle mass and function

Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is g...

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Detalles Bibliográficos
Autores principales: Lipina, Christopher, Hundal, Harinder S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377414/
https://www.ncbi.nlm.nih.gov/pubmed/27897400
http://dx.doi.org/10.1002/jcsm.12144
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author Lipina, Christopher
Hundal, Harinder S
author_facet Lipina, Christopher
Hundal, Harinder S
author_sort Lipina, Christopher
collection PubMed
description Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.
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spelling pubmed-53774142017-04-05 Lipid modulation of skeletal muscle mass and function Lipina, Christopher Hundal, Harinder S J Cachexia Sarcopenia Muscle Review Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention. John Wiley and Sons Inc. 2016-10-08 2017-04 /pmc/articles/PMC5377414/ /pubmed/27897400 http://dx.doi.org/10.1002/jcsm.12144 Text en © 2016 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lipina, Christopher
Hundal, Harinder S
Lipid modulation of skeletal muscle mass and function
title Lipid modulation of skeletal muscle mass and function
title_full Lipid modulation of skeletal muscle mass and function
title_fullStr Lipid modulation of skeletal muscle mass and function
title_full_unstemmed Lipid modulation of skeletal muscle mass and function
title_short Lipid modulation of skeletal muscle mass and function
title_sort lipid modulation of skeletal muscle mass and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377414/
https://www.ncbi.nlm.nih.gov/pubmed/27897400
http://dx.doi.org/10.1002/jcsm.12144
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