Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics

T cell–mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key molecules to modulate T cell functions; however, in many cases, we cannot evaluate the drug candidates in animal experiments because the the...

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Detalles Bibliográficos
Autores principales: Ueda, Otoya, Wada, Naoko A., Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377452/
https://www.ncbi.nlm.nih.gov/pubmed/28368009
http://dx.doi.org/10.1038/srep45839

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