Cargando…

Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases

Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same...

Descripción completa

Detalles Bibliográficos
Autores principales: Sabeti, Faran, James, Andrew C., Carle, Corinne F., Essex, Rohan W., Bell, Andrew, Maddess, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377468/
https://www.ncbi.nlm.nih.gov/pubmed/28368051
http://dx.doi.org/10.1038/srep45847
_version_ 1782519322917208064
author Sabeti, Faran
James, Andrew C.
Carle, Corinne F.
Essex, Rohan W.
Bell, Andrew
Maddess, Ted
author_facet Sabeti, Faran
James, Andrew C.
Carle, Corinne F.
Essex, Rohan W.
Bell, Andrew
Maddess, Ted
author_sort Sabeti, Faran
collection PubMed
description Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same day in the same patients. The pupil control system receives input from the extra-striate cortex, so we also examined evidence for such input. We recruited subjects with early type 2 diabetes (T2D) with no retinopathy, and patients with unilateral exudative AMD. Population average responses of the diabetes patients, and the normal fellow eyes of AMD patients, showed multiple regions of significant hypersensitivity (p < 0.05) on both mfPOP and mfVEPs. For mfVEPs the occipital electrodes showed fewer hypersensitive regions than the surrounding electrodes. More advanced AMD showed regions of suppression becoming centrally concentrated in the exudative AMD areas. Thus, mfVEP electrodes biased towards extra-striate cortical responses (surround electrodes) appeared to show similar hypersensitive visual field locations to mfPOP in early stage diabetic and AMD damage. Our findings suggest that hypersensitive regions may be a potential biomarker for future development of AMD or non-proliferative diabetic retinopathy, and may be more informative than visual acuity which remains largely undisturbed during early disease.
format Online
Article
Text
id pubmed-5377468
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-53774682017-04-10 Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases Sabeti, Faran James, Andrew C. Carle, Corinne F. Essex, Rohan W. Bell, Andrew Maddess, Ted Sci Rep Article Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same day in the same patients. The pupil control system receives input from the extra-striate cortex, so we also examined evidence for such input. We recruited subjects with early type 2 diabetes (T2D) with no retinopathy, and patients with unilateral exudative AMD. Population average responses of the diabetes patients, and the normal fellow eyes of AMD patients, showed multiple regions of significant hypersensitivity (p < 0.05) on both mfPOP and mfVEPs. For mfVEPs the occipital electrodes showed fewer hypersensitive regions than the surrounding electrodes. More advanced AMD showed regions of suppression becoming centrally concentrated in the exudative AMD areas. Thus, mfVEP electrodes biased towards extra-striate cortical responses (surround electrodes) appeared to show similar hypersensitive visual field locations to mfPOP in early stage diabetic and AMD damage. Our findings suggest that hypersensitive regions may be a potential biomarker for future development of AMD or non-proliferative diabetic retinopathy, and may be more informative than visual acuity which remains largely undisturbed during early disease. Nature Publishing Group 2017-04-03 /pmc/articles/PMC5377468/ /pubmed/28368051 http://dx.doi.org/10.1038/srep45847 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sabeti, Faran
James, Andrew C.
Carle, Corinne F.
Essex, Rohan W.
Bell, Andrew
Maddess, Ted
Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
title Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
title_full Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
title_fullStr Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
title_full_unstemmed Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
title_short Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
title_sort comparing multifocal pupillographic objective perimetry (mfpop) and multifocal visual evoked potentials (mfvep) in retinal diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377468/
https://www.ncbi.nlm.nih.gov/pubmed/28368051
http://dx.doi.org/10.1038/srep45847
work_keys_str_mv AT sabetifaran comparingmultifocalpupillographicobjectiveperimetrymfpopandmultifocalvisualevokedpotentialsmfvepinretinaldiseases
AT jamesandrewc comparingmultifocalpupillographicobjectiveperimetrymfpopandmultifocalvisualevokedpotentialsmfvepinretinaldiseases
AT carlecorinnef comparingmultifocalpupillographicobjectiveperimetrymfpopandmultifocalvisualevokedpotentialsmfvepinretinaldiseases
AT essexrohanw comparingmultifocalpupillographicobjectiveperimetrymfpopandmultifocalvisualevokedpotentialsmfvepinretinaldiseases
AT bellandrew comparingmultifocalpupillographicobjectiveperimetrymfpopandmultifocalvisualevokedpotentialsmfvepinretinaldiseases
AT maddessted comparingmultifocalpupillographicobjectiveperimetrymfpopandmultifocalvisualevokedpotentialsmfvepinretinaldiseases