Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1

Human peroxidasin 1 is a homotrimeric multidomain peroxidase that is secreted to the extracellular matrix. The heme enzyme was shown to release hypobromous acid that mediates the formation of specific covalent sulfilimine bonds to reinforce collagen IV in basement membranes. Maturation by proteolyti...

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Detalles Bibliográficos
Autores principales: Paumann-Page, Martina, Katz, Romy-Sophie, Bellei, Marzia, Schwartz, Irene, Edenhofer, Eva, Sevcnikar, Benjamin, Soudi, Monika, Hofbauer, Stefan, Battistuzzi, Gianantonio, Furtmüller, Paul G., Obinger, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377774/
https://www.ncbi.nlm.nih.gov/pubmed/28154175
http://dx.doi.org/10.1074/jbc.M117.775213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377774/
https://www.ncbi.nlm.nih.gov/pubmed/28154175
http://dx.doi.org/10.1074/jbc.M117.775213

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