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Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
[Image: see text] Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378067/ https://www.ncbi.nlm.nih.gov/pubmed/28392884 http://dx.doi.org/10.1021/acs.jpcc.6b12097 |
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author | Colell, Johannes F. P. Logan, Angus W. J. Zhou, Zijian Shchepin, Roman V. Barskiy, Danila A. Ortiz, Gerardo X. Wang, Qiu Malcolmson, Steven J. Chekmenev, Eduard Y. Warren, Warren S. Theis, Thomas |
author_facet | Colell, Johannes F. P. Logan, Angus W. J. Zhou, Zijian Shchepin, Roman V. Barskiy, Danila A. Ortiz, Gerardo X. Wang, Qiu Malcolmson, Steven J. Chekmenev, Eduard Y. Warren, Warren S. Theis, Thomas |
author_sort | Colell, Johannes F. P. |
collection | PubMed |
description | [Image: see text] Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that (15)N-SABRE works more efficiently and on a wider range of substrates than (1)H-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-15 offers significantly extended T(1) times of up to 12 minutes. Long T(1) times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization levels in excess of 10% on several compounds. |
format | Online Article Text |
id | pubmed-5378067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-53780672018-02-02 Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange Colell, Johannes F. P. Logan, Angus W. J. Zhou, Zijian Shchepin, Roman V. Barskiy, Danila A. Ortiz, Gerardo X. Wang, Qiu Malcolmson, Steven J. Chekmenev, Eduard Y. Warren, Warren S. Theis, Thomas J Phys Chem C Nanomater Interfaces [Image: see text] Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that (15)N-SABRE works more efficiently and on a wider range of substrates than (1)H-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-15 offers significantly extended T(1) times of up to 12 minutes. Long T(1) times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization levels in excess of 10% on several compounds. American Chemical Society 2017-02-02 2017-03-30 /pmc/articles/PMC5378067/ /pubmed/28392884 http://dx.doi.org/10.1021/acs.jpcc.6b12097 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Colell, Johannes F. P. Logan, Angus W. J. Zhou, Zijian Shchepin, Roman V. Barskiy, Danila A. Ortiz, Gerardo X. Wang, Qiu Malcolmson, Steven J. Chekmenev, Eduard Y. Warren, Warren S. Theis, Thomas Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange |
title | Generalizing, Extending, and Maximizing Nitrogen-15
Hyperpolarization Induced by Parahydrogen in Reversible Exchange |
title_full | Generalizing, Extending, and Maximizing Nitrogen-15
Hyperpolarization Induced by Parahydrogen in Reversible Exchange |
title_fullStr | Generalizing, Extending, and Maximizing Nitrogen-15
Hyperpolarization Induced by Parahydrogen in Reversible Exchange |
title_full_unstemmed | Generalizing, Extending, and Maximizing Nitrogen-15
Hyperpolarization Induced by Parahydrogen in Reversible Exchange |
title_short | Generalizing, Extending, and Maximizing Nitrogen-15
Hyperpolarization Induced by Parahydrogen in Reversible Exchange |
title_sort | generalizing, extending, and maximizing nitrogen-15
hyperpolarization induced by parahydrogen in reversible exchange |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378067/ https://www.ncbi.nlm.nih.gov/pubmed/28392884 http://dx.doi.org/10.1021/acs.jpcc.6b12097 |
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