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High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index

OBJECTIVES: High Bone Mass (HBM) is associated with (a) radiographic knee osteoarthritis (OA), partly mediated by increased BMI, and (b) pelvic enthesophytes and hip osteophytes, suggestive of a bone-forming phenotype. We aimed to establish whether HBM is associated with radiographic features of OA...

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Autores principales: Gregson, C.L., Hardcastle, S.A., Murphy, A., Faber, B., Fraser, W.D., Williams, M., Davey Smith, G., Tobias, J.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378151/
https://www.ncbi.nlm.nih.gov/pubmed/28082078
http://dx.doi.org/10.1016/j.bone.2017.01.005
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author Gregson, C.L.
Hardcastle, S.A.
Murphy, A.
Faber, B.
Fraser, W.D.
Williams, M.
Davey Smith, G.
Tobias, J.H.
author_facet Gregson, C.L.
Hardcastle, S.A.
Murphy, A.
Faber, B.
Fraser, W.D.
Williams, M.
Davey Smith, G.
Tobias, J.H.
author_sort Gregson, C.L.
collection PubMed
description OBJECTIVES: High Bone Mass (HBM) is associated with (a) radiographic knee osteoarthritis (OA), partly mediated by increased BMI, and (b) pelvic enthesophytes and hip osteophytes, suggestive of a bone-forming phenotype. We aimed to establish whether HBM is associated with radiographic features of OA in non-weight-bearing (hand) joints, and whether such OA demonstrates a bone-forming phenotype. METHODS: HBM cases (BMD Z-scores ≥  + 3.2) were compared with family controls. A blinded assessor graded all PA hand radiographs for: osteophytes (0–3), joint space narrowing (JSN) (0–3), subchondral sclerosis (0–1), at the index Distal Interphalangeal Joint (DIPJ) and 1st Carpometacarpal Joint (CMCJ), using an established atlas. Analyses used a random effects logistic regression model, adjusting a priori for age and gender. Mediating roles of BMI and bone turnover markers (BTMs) were explored by further adjustment. RESULTS: 314 HBM cases (mean age 61.1 years, 74% female) and 183 controls (54.3 years, 46% female) were included. Osteophytes (grade ≥ 1) were more common in HBM (DIPJ: 67% vs. 45%, CMCJ: 69% vs. 50%), with adjusted OR [95% CI] 1.82 [1.11, 2.97], p = 0.017 and 1.89 [1.19, 3.01], p = 0.007 respectively; no differences were seen in JSN. Further adjustment for BMI failed to attenuate ORs for osteophytes in HBM cases vs. controls; DIPJ 1.72 [1.05, 2.83], p = 0.032, CMCJ 1.76 [1.00, 3.06], p = 0.049. Adjustment for BTMs (concentrations lower amongst HBM cases) did not attenuate ORs. CONCLUSIONS: HBM is positively associated with OA in non-weight-bearing joints, independent of BMI. HBM-associated OA is characterised by osteophytes, consistent with a bone-forming phenotype, rather than JSN reflecting cartilage loss. Systemic factors (e.g. genetic architecture) which govern HBM may also increase bone-forming OA risk.
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spelling pubmed-53781512017-04-07 High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index Gregson, C.L. Hardcastle, S.A. Murphy, A. Faber, B. Fraser, W.D. Williams, M. Davey Smith, G. Tobias, J.H. Bone Full Length Article OBJECTIVES: High Bone Mass (HBM) is associated with (a) radiographic knee osteoarthritis (OA), partly mediated by increased BMI, and (b) pelvic enthesophytes and hip osteophytes, suggestive of a bone-forming phenotype. We aimed to establish whether HBM is associated with radiographic features of OA in non-weight-bearing (hand) joints, and whether such OA demonstrates a bone-forming phenotype. METHODS: HBM cases (BMD Z-scores ≥  + 3.2) were compared with family controls. A blinded assessor graded all PA hand radiographs for: osteophytes (0–3), joint space narrowing (JSN) (0–3), subchondral sclerosis (0–1), at the index Distal Interphalangeal Joint (DIPJ) and 1st Carpometacarpal Joint (CMCJ), using an established atlas. Analyses used a random effects logistic regression model, adjusting a priori for age and gender. Mediating roles of BMI and bone turnover markers (BTMs) were explored by further adjustment. RESULTS: 314 HBM cases (mean age 61.1 years, 74% female) and 183 controls (54.3 years, 46% female) were included. Osteophytes (grade ≥ 1) were more common in HBM (DIPJ: 67% vs. 45%, CMCJ: 69% vs. 50%), with adjusted OR [95% CI] 1.82 [1.11, 2.97], p = 0.017 and 1.89 [1.19, 3.01], p = 0.007 respectively; no differences were seen in JSN. Further adjustment for BMI failed to attenuate ORs for osteophytes in HBM cases vs. controls; DIPJ 1.72 [1.05, 2.83], p = 0.032, CMCJ 1.76 [1.00, 3.06], p = 0.049. Adjustment for BTMs (concentrations lower amongst HBM cases) did not attenuate ORs. CONCLUSIONS: HBM is positively associated with OA in non-weight-bearing joints, independent of BMI. HBM-associated OA is characterised by osteophytes, consistent with a bone-forming phenotype, rather than JSN reflecting cartilage loss. Systemic factors (e.g. genetic architecture) which govern HBM may also increase bone-forming OA risk. Elsevier Science 2017-04 /pmc/articles/PMC5378151/ /pubmed/28082078 http://dx.doi.org/10.1016/j.bone.2017.01.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Full Length Article
Gregson, C.L.
Hardcastle, S.A.
Murphy, A.
Faber, B.
Fraser, W.D.
Williams, M.
Davey Smith, G.
Tobias, J.H.
High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
title High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
title_full High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
title_fullStr High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
title_full_unstemmed High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
title_short High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
title_sort high bone mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378151/
https://www.ncbi.nlm.nih.gov/pubmed/28082078
http://dx.doi.org/10.1016/j.bone.2017.01.005
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