Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells

Although long non‐coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lncRNA , POTEF‐AS1, whose expression was regulated by androgen receptor in tw...

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Detalles Bibliográficos
Autores principales: Misawa, Aya, Takayama, Ken‐ichi, Fujimura, Tetsuya, Homma, Yukio, Suzuki, Yutaka, Inoue, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378265/
https://www.ncbi.nlm.nih.gov/pubmed/28032932
http://dx.doi.org/10.1111/cas.13151
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author Misawa, Aya
Takayama, Ken‐ichi
Fujimura, Tetsuya
Homma, Yukio
Suzuki, Yutaka
Inoue, Satoshi
author_facet Misawa, Aya
Takayama, Ken‐ichi
Fujimura, Tetsuya
Homma, Yukio
Suzuki, Yutaka
Inoue, Satoshi
author_sort Misawa, Aya
collection PubMed
description Although long non‐coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lncRNA , POTEF‐AS1, whose expression was regulated by androgen receptor in two androgen‐dependent cells by using directional RNA sequencing analysis. POTEF‐AS1 promoted cell growth, repressed genes related to the Toll‐like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel‐treated LNCaP cells. These findings suggest that POTEF‐AS1 would play a key role in the progression of prostate cancer by repressing Toll‐like receptor signaling.
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spelling pubmed-53782652017-04-07 Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells Misawa, Aya Takayama, Ken‐ichi Fujimura, Tetsuya Homma, Yukio Suzuki, Yutaka Inoue, Satoshi Cancer Sci Original Articles Although long non‐coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lncRNA , POTEF‐AS1, whose expression was regulated by androgen receptor in two androgen‐dependent cells by using directional RNA sequencing analysis. POTEF‐AS1 promoted cell growth, repressed genes related to the Toll‐like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel‐treated LNCaP cells. These findings suggest that POTEF‐AS1 would play a key role in the progression of prostate cancer by repressing Toll‐like receptor signaling. John Wiley and Sons Inc. 2017-04-03 2017-03 /pmc/articles/PMC5378265/ /pubmed/28032932 http://dx.doi.org/10.1111/cas.13151 Text en © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Misawa, Aya
Takayama, Ken‐ichi
Fujimura, Tetsuya
Homma, Yukio
Suzuki, Yutaka
Inoue, Satoshi
Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
title Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
title_full Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
title_fullStr Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
title_full_unstemmed Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
title_short Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
title_sort androgen‐induced lncrna potef‐as1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378265/
https://www.ncbi.nlm.nih.gov/pubmed/28032932
http://dx.doi.org/10.1111/cas.13151
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