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Degree of methylation burden is determined by the exposure period to carcinogenic factors

Aberrant DNA methylation accumulated in normal tissues, namely methylation burden, is associated with risk of carcinogenesis. The levels of methylation burden are known to be influenced by multiple factors, such as genetic factors and strengths of carcinogenic factors. However, the impact of the deg...

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Detalles Bibliográficos
Autores principales: Takeshima, Hideyuki, Niwa, Tohru, Toyoda, Takeshi, Wakabayashi, Mika, Yamashita, Satoshi, Ushijima, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378290/
https://www.ncbi.nlm.nih.gov/pubmed/27992956
http://dx.doi.org/10.1111/cas.13136