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Imaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and dru...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302/ https://www.ncbi.nlm.nih.gov/pubmed/27725679 http://dx.doi.org/10.1038/nrclinonc.2016.162 |
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| author | O’Connor, James P. B. Aboagye, Eric O. Adams, Judith E. Aerts, Hugo J. W. L. Barrington, Sally F. Beer, Ambros J. Boellaard, Ronald Bohndiek, Sarah E. Brady, Michael Brown, Gina Buckley, David L. Chenevert, Thomas L. Clarke, Laurence P. Collette, Sandra Cook, Gary J. deSouza, Nandita M. Dickson, John C. Dive, Caroline Evelhoch, Jeffrey L. Faivre-Finn, Corinne Gallagher, Ferdia A. Gilbert, Fiona J. Gillies, Robert J. Goh, Vicky Griffiths, John R. Groves, Ashley M. Halligan, Steve Harris, Adrian L. Hawkes, David J. Hoekstra, Otto S. Huang, Erich P. Hutton, Brian F. Jackson, Edward F. Jayson, Gordon C. Jones, Andrew Koh, Dow-Mu Lacombe, Denis Lambin, Philippe Lassau, Nathalie Leach, Martin O. Lee, Ting-Yim Leen, Edward L. Lewis, Jason S. Liu, Yan Lythgoe, Mark F. Manoharan, Prakash Maxwell, Ross J. Miles, Kenneth A. Morgan, Bruno Morris, Steve Ng, Tony Padhani, Anwar R. Parker, Geoff J. M. Partridge, Mike Pathak, Arvind P. Peet, Andrew C. Punwani, Shonit Reynolds, Andrew R. Robinson, Simon P. Shankar, Lalitha K. Sharma, Ricky A. Soloviev, Dmitry Stroobants, Sigrid Sullivan, Daniel C. Taylor, Stuart A. Tofts, Paul S. Tozer, Gillian M. van Herk, Marcel Walker-Samuel, Simon Wason, James Williams, Kaye J. Workman, Paul Yankeelov, Thomas E. Brindle, Kevin M. McShane, Lisa M. Jackson, Alan Waterton, John C. |
| author_facet | O’Connor, James P. B. Aboagye, Eric O. Adams, Judith E. Aerts, Hugo J. W. L. Barrington, Sally F. Beer, Ambros J. Boellaard, Ronald Bohndiek, Sarah E. Brady, Michael Brown, Gina Buckley, David L. Chenevert, Thomas L. Clarke, Laurence P. Collette, Sandra Cook, Gary J. deSouza, Nandita M. Dickson, John C. Dive, Caroline Evelhoch, Jeffrey L. Faivre-Finn, Corinne Gallagher, Ferdia A. Gilbert, Fiona J. Gillies, Robert J. Goh, Vicky Griffiths, John R. Groves, Ashley M. Halligan, Steve Harris, Adrian L. Hawkes, David J. Hoekstra, Otto S. Huang, Erich P. Hutton, Brian F. Jackson, Edward F. Jayson, Gordon C. Jones, Andrew Koh, Dow-Mu Lacombe, Denis Lambin, Philippe Lassau, Nathalie Leach, Martin O. Lee, Ting-Yim Leen, Edward L. Lewis, Jason S. Liu, Yan Lythgoe, Mark F. Manoharan, Prakash Maxwell, Ross J. Miles, Kenneth A. Morgan, Bruno Morris, Steve Ng, Tony Padhani, Anwar R. Parker, Geoff J. M. Partridge, Mike Pathak, Arvind P. Peet, Andrew C. Punwani, Shonit Reynolds, Andrew R. Robinson, Simon P. Shankar, Lalitha K. Sharma, Ricky A. Soloviev, Dmitry Stroobants, Sigrid Sullivan, Daniel C. Taylor, Stuart A. Tofts, Paul S. Tozer, Gillian M. van Herk, Marcel Walker-Samuel, Simon Wason, James Williams, Kaye J. Workman, Paul Yankeelov, Thomas E. Brindle, Kevin M. McShane, Lisa M. Jackson, Alan Waterton, John C. |
| author_sort | O’Connor, James P. B. |
| collection | PubMed |
| description | Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing ‘translational gaps’ through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored ‘roadmap’. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use. |
| format | Online Article Text |
| id | pubmed-5378302 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53783022017-04-03 Imaging biomarker roadmap for cancer studies O’Connor, James P. B. Aboagye, Eric O. Adams, Judith E. Aerts, Hugo J. W. L. Barrington, Sally F. Beer, Ambros J. Boellaard, Ronald Bohndiek, Sarah E. Brady, Michael Brown, Gina Buckley, David L. Chenevert, Thomas L. Clarke, Laurence P. Collette, Sandra Cook, Gary J. deSouza, Nandita M. Dickson, John C. Dive, Caroline Evelhoch, Jeffrey L. Faivre-Finn, Corinne Gallagher, Ferdia A. Gilbert, Fiona J. Gillies, Robert J. Goh, Vicky Griffiths, John R. Groves, Ashley M. Halligan, Steve Harris, Adrian L. Hawkes, David J. Hoekstra, Otto S. Huang, Erich P. Hutton, Brian F. Jackson, Edward F. Jayson, Gordon C. Jones, Andrew Koh, Dow-Mu Lacombe, Denis Lambin, Philippe Lassau, Nathalie Leach, Martin O. Lee, Ting-Yim Leen, Edward L. Lewis, Jason S. Liu, Yan Lythgoe, Mark F. Manoharan, Prakash Maxwell, Ross J. Miles, Kenneth A. Morgan, Bruno Morris, Steve Ng, Tony Padhani, Anwar R. Parker, Geoff J. M. Partridge, Mike Pathak, Arvind P. Peet, Andrew C. Punwani, Shonit Reynolds, Andrew R. Robinson, Simon P. Shankar, Lalitha K. Sharma, Ricky A. Soloviev, Dmitry Stroobants, Sigrid Sullivan, Daniel C. Taylor, Stuart A. Tofts, Paul S. Tozer, Gillian M. van Herk, Marcel Walker-Samuel, Simon Wason, James Williams, Kaye J. Workman, Paul Yankeelov, Thomas E. Brindle, Kevin M. McShane, Lisa M. Jackson, Alan Waterton, John C. Nat Rev Clin Oncol Article Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing ‘translational gaps’ through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored ‘roadmap’. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use. 2016-10-11 2017-03 /pmc/articles/PMC5378302/ /pubmed/27725679 http://dx.doi.org/10.1038/nrclinonc.2016.162 Text en http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article O’Connor, James P. B. Aboagye, Eric O. Adams, Judith E. Aerts, Hugo J. W. L. Barrington, Sally F. Beer, Ambros J. Boellaard, Ronald Bohndiek, Sarah E. Brady, Michael Brown, Gina Buckley, David L. Chenevert, Thomas L. Clarke, Laurence P. Collette, Sandra Cook, Gary J. deSouza, Nandita M. Dickson, John C. Dive, Caroline Evelhoch, Jeffrey L. Faivre-Finn, Corinne Gallagher, Ferdia A. Gilbert, Fiona J. Gillies, Robert J. Goh, Vicky Griffiths, John R. Groves, Ashley M. Halligan, Steve Harris, Adrian L. Hawkes, David J. Hoekstra, Otto S. Huang, Erich P. Hutton, Brian F. Jackson, Edward F. Jayson, Gordon C. Jones, Andrew Koh, Dow-Mu Lacombe, Denis Lambin, Philippe Lassau, Nathalie Leach, Martin O. Lee, Ting-Yim Leen, Edward L. Lewis, Jason S. Liu, Yan Lythgoe, Mark F. Manoharan, Prakash Maxwell, Ross J. Miles, Kenneth A. Morgan, Bruno Morris, Steve Ng, Tony Padhani, Anwar R. Parker, Geoff J. M. Partridge, Mike Pathak, Arvind P. Peet, Andrew C. Punwani, Shonit Reynolds, Andrew R. Robinson, Simon P. Shankar, Lalitha K. Sharma, Ricky A. Soloviev, Dmitry Stroobants, Sigrid Sullivan, Daniel C. Taylor, Stuart A. Tofts, Paul S. Tozer, Gillian M. van Herk, Marcel Walker-Samuel, Simon Wason, James Williams, Kaye J. Workman, Paul Yankeelov, Thomas E. Brindle, Kevin M. McShane, Lisa M. Jackson, Alan Waterton, John C. Imaging biomarker roadmap for cancer studies |
| title | Imaging biomarker roadmap for cancer studies |
| title_full | Imaging biomarker roadmap for cancer studies |
| title_fullStr | Imaging biomarker roadmap for cancer studies |
| title_full_unstemmed | Imaging biomarker roadmap for cancer studies |
| title_short | Imaging biomarker roadmap for cancer studies |
| title_sort | imaging biomarker roadmap for cancer studies |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302/ https://www.ncbi.nlm.nih.gov/pubmed/27725679 http://dx.doi.org/10.1038/nrclinonc.2016.162 |
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