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Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization
Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378338/ https://www.ncbi.nlm.nih.gov/pubmed/28369143 http://dx.doi.org/10.1371/journal.pone.0174633 |
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author | Nagasawa-Masuda, Ayumi Terai, Kenta |
author_facet | Nagasawa-Masuda, Ayumi Terai, Kenta |
author_sort | Nagasawa-Masuda, Ayumi |
collection | PubMed |
description | Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal part of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression. These results implicate a novel role of Yap/Taz in vascular regression. |
format | Online Article Text |
id | pubmed-5378338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53783382017-04-07 Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization Nagasawa-Masuda, Ayumi Terai, Kenta PLoS One Research Article Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal part of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression. These results implicate a novel role of Yap/Taz in vascular regression. Public Library of Science 2017-04-03 /pmc/articles/PMC5378338/ /pubmed/28369143 http://dx.doi.org/10.1371/journal.pone.0174633 Text en © 2017 Nagasawa-Masuda, Terai http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nagasawa-Masuda, Ayumi Terai, Kenta Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |
title | Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |
title_full | Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |
title_fullStr | Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |
title_full_unstemmed | Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |
title_short | Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |
title_sort | yap/taz transcriptional activity is essential for vascular regression via ctgf expression and actin polymerization |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378338/ https://www.ncbi.nlm.nih.gov/pubmed/28369143 http://dx.doi.org/10.1371/journal.pone.0174633 |
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