Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma

Sustained activation of JAK/STAT3 signaling pathway is classically described in Multiple Myeloma (MM). One explanation could be the silencing of the JAK/STAT suppressor genes, through the hypermethylation of SHP-1 and SOCS-1, previously demonstrated in MM cell lines or in whole bone marrow aspirates...

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Detalles Bibliográficos
Autores principales: Beldi-Ferchiou, Asma, Skouri, Nour, Ben Ali, Cyrine, Safra, Ines, Abdelkefi, Abderrahman, Ladeb, Saloua, Mrad, Karima, Ben Othman, Tarek, Ben Ahmed, Mélika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378363/
https://www.ncbi.nlm.nih.gov/pubmed/28369102
http://dx.doi.org/10.1371/journal.pone.0174835

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