Mechanism of ribosome rescue by ArfA and RF2

ArfA rescues ribosomes stalled on truncated mRNAs by recruiting release factor RF2, which normally binds stop codons to catalyze peptide release. We report two 3.2 Å resolution cryo-EM structures – determined from a single sample – of the 70S ribosome with ArfA•RF2 in the A site. In both states, the...

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Detalles Bibliográficos
Autores principales: Demo, Gabriel, Svidritskiy, Egor, Madireddy, Rohini, Diaz-Avalos, Ruben, Grant, Timothy, Grigorieff, Nikolaus, Sousa, Duncan, Korostelev, Andrei A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378476/
https://www.ncbi.nlm.nih.gov/pubmed/28300532
http://dx.doi.org/10.7554/eLife.23687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378476/
https://www.ncbi.nlm.nih.gov/pubmed/28300532
http://dx.doi.org/10.7554/eLife.23687

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