[(18)F]FDG PET signal is driven by astroglial glutamate transport

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide the first positron emission tomography (PET) evidence that activation of the astrocytic glutamate transport via GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our result...

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Detalles Bibliográficos
Autores principales: Zimmer, Eduardo R., Parent, Maxime J., Souza, Débora G., Leuzy, Antoine, Lecrux, Clotilde, Kim, Hyoung-Ihl, Gauthier, Serge, Pellerin, Luc, Hamel, Edith, Rosa-Neto, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378483/
https://www.ncbi.nlm.nih.gov/pubmed/28135241
http://dx.doi.org/10.1038/nn.4492
Descripción
Sumario:Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide the first positron emission tomography (PET) evidence that activation of the astrocytic glutamate transport via GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG PET data, whereby astrocytes would be recognized to contribute significantly to the [(18)F]FDG signal.

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