[(18)F]FDG PET signal is driven by astroglial glutamate transport

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide the first positron emission tomography (PET) evidence that activation of the astrocytic glutamate transport via GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our result...

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Autores principales: Zimmer, Eduardo R., Parent, Maxime J., Souza, Débora G., Leuzy, Antoine, Lecrux, Clotilde, Kim, Hyoung-Ihl, Gauthier, Serge, Pellerin, Luc, Hamel, Edith, Rosa-Neto, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378483/
https://www.ncbi.nlm.nih.gov/pubmed/28135241
http://dx.doi.org/10.1038/nn.4492
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author Zimmer, Eduardo R.
Parent, Maxime J.
Souza, Débora G.
Leuzy, Antoine
Lecrux, Clotilde
Kim, Hyoung-Ihl
Gauthier, Serge
Pellerin, Luc
Hamel, Edith
Rosa-Neto, Pedro
author_facet Zimmer, Eduardo R.
Parent, Maxime J.
Souza, Débora G.
Leuzy, Antoine
Lecrux, Clotilde
Kim, Hyoung-Ihl
Gauthier, Serge
Pellerin, Luc
Hamel, Edith
Rosa-Neto, Pedro
author_sort Zimmer, Eduardo R.
collection PubMed
description Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide the first positron emission tomography (PET) evidence that activation of the astrocytic glutamate transport via GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG PET data, whereby astrocytes would be recognized to contribute significantly to the [(18)F]FDG signal.
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spelling pubmed-53784832017-09-01 [(18)F]FDG PET signal is driven by astroglial glutamate transport Zimmer, Eduardo R. Parent, Maxime J. Souza, Débora G. Leuzy, Antoine Lecrux, Clotilde Kim, Hyoung-Ihl Gauthier, Serge Pellerin, Luc Hamel, Edith Rosa-Neto, Pedro Nat Neurosci Article Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide the first positron emission tomography (PET) evidence that activation of the astrocytic glutamate transport via GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG PET data, whereby astrocytes would be recognized to contribute significantly to the [(18)F]FDG signal. 2017-01-30 2017-03 /pmc/articles/PMC5378483/ /pubmed/28135241 http://dx.doi.org/10.1038/nn.4492 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zimmer, Eduardo R.
Parent, Maxime J.
Souza, Débora G.
Leuzy, Antoine
Lecrux, Clotilde
Kim, Hyoung-Ihl
Gauthier, Serge
Pellerin, Luc
Hamel, Edith
Rosa-Neto, Pedro
[(18)F]FDG PET signal is driven by astroglial glutamate transport
title [(18)F]FDG PET signal is driven by astroglial glutamate transport
title_full [(18)F]FDG PET signal is driven by astroglial glutamate transport
title_fullStr [(18)F]FDG PET signal is driven by astroglial glutamate transport
title_full_unstemmed [(18)F]FDG PET signal is driven by astroglial glutamate transport
title_short [(18)F]FDG PET signal is driven by astroglial glutamate transport
title_sort [(18)f]fdg pet signal is driven by astroglial glutamate transport
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378483/
https://www.ncbi.nlm.nih.gov/pubmed/28135241
http://dx.doi.org/10.1038/nn.4492
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