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Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders

The unique biology of RNA binding proteins is altering our view of the genesis of protein misfolding diseases. These proteins use aggregation of low complexity domains (LCDs) as a means to regulate the localization and utilization of RNA by forming RNA granules, such as stress granules, transport gr...

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Detalles Bibliográficos
Autores principales: Maziuk, Brandon, Ballance, Heather I., Wolozin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378767/
https://www.ncbi.nlm.nih.gov/pubmed/28420962
http://dx.doi.org/10.3389/fnmol.2017.00089