Cargando…

Gabapentin Attenuates Ocular Inflammation: In vitro and In vivo Studies

To investigate the effects of gabapentin, a structural analog of γ-amino butyric acid (GABA), on the inflammatory response of lipopolysaccharide (LPS)-stimulated rabbit corneal cells (SIRC) and on endotoxin-induced uveitis (EIU) in rabbits. We investigated the LPS-induced expression of several infla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anfuso, Carmelina D., Olivieri, Melania, Fidilio, Annamaria, Lupo, Gabriella, Rusciano, Dario, Pezzino, Salvatore, Gagliano, Caterina, Drago, Filippo, Bucolo, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378778/ https://www.ncbi.nlm.nih.gov/pubmed/28420991 http://dx.doi.org/10.3389/fphar.2017.00173

Ejemplares similares

Effects of Topical Gabapentin on Ocular Pain and Tear Secretion
por: Cammalleri, Maurizio, et al.
Publicado: (2021)

Atropine Differentially Modulates ECM Production by Ocular Fibroblasts, and Its Ocular Surface Toxicity Is Blunted by Colostrum
por: Cristaldi, Martina, et al.
Publicado: (2020)

[Corrigendum] Melanogenesis in uveal melanoma cells: Effect of argan oil
por: Caporarello, Nunzia, et al.
Publicado: (2023)

Vitamin D(3) preserves blood retinal barrier integrity in an in vitro model of diabetic retinopathy
por: Lazzara, Francesca, et al.
Publicado: (2022)

Ocular drug delivery: a clue from nanotechnology
por: Bucolo, Claudio, et al.
Publicado: (2012)

Acidic Mammalian Chitinase and the Eye: Implications for Ocular Inflammatory Diseases
por: Bucolo, Claudio, et al.
Publicado: (2011)

Ocular Pharmacological Profile of Hydrocortisone in Dry Eye Disease
por: Bucolo, Claudio, et al.
Publicado: (2019)

Anti-angiogenic Therapy in Cancer: Downsides and New Pivots for Precision Medicine
por: Lupo, Gabriella, et al.
Publicado: (2017)

Retinal Protection and Distribution of Curcumin in Vitro and in Vivo
por: Platania, Chiara B. M., et al.
Publicado: (2018)

Activation of the VEGF-A/ERK/PLA2 Axis Mediates Early Retinal Endothelial Cell Damage Induced by High Glucose: New Insight from an In Vitro Model of Diabetic Retinopathy
por: Giurdanella, Giovanni, et al.
Publicado: (2020)

Potential drug mechanism(s) targeting the contractile status of hepatic stellate cells
por: Bucolo, Claudio, et al.
Publicado: (2012)

Effects of Topical Fucosyl-Lactose, a Milk Oligosaccharide, on Dry Eye Model: An Example of Nutraceutical Candidate
por: Bucolo, Claudio, et al.
Publicado: (2015)

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2017)

Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition
por: Maugeri, Grazia, et al.
Publicado: (2021)

Apixaban Enhances Vasodilatation Mediated by Protease-Activated Receptor 2 in Isolated Rat Arteries
por: Villari, Ambra, et al.
Publicado: (2017)

Classical VEGF, Notch and Ang signalling in cancer angiogenesis, alternative approaches and future directions
por: Caporarello, Nunzia, et al.
Publicado: (2017)

Corneal wound healing and nerve regeneration by novel ophthalmic formulations based on cross-linked sodium hyaluronate, taurine, vitamin B6, and vitamin B12
por: Bucolo, Claudio, et al.
Publicado: (2023)

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2017)

Editorial: Ocular Pharmacology: Recent Breakthroughs and Unmet Needs
por: Bucolo, Claudio, et al.
Publicado: (2022)

A New Human Blood–Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes
por: Fresta, Claudia G., et al.
Publicado: (2020)

The Anti-Inflammatory Effect of the β1-Adrenergic Receptor Antagonist Metoprolol on High Glucose Treated Human Microvascular Retinal Endothelial Cells
por: Giurdanella, Giovanni, et al.
Publicado: (2021)

Ferulic Acid-Loaded Polymeric Nanoparticles for Potential Ocular Delivery
por: Romeo, Alessia, et al.
Publicado: (2021)

Dihydrotanshinone, a Natural Diterpenoid, Preserves Blood-Retinal Barrier Integrity via P2X7 Receptor
por: Fresta, Claudia Giuseppina, et al.
Publicado: (2020)

Carnosine Counteracts the Molecular Alterations Aβ Oligomers-Induced in Human Retinal Pigment Epithelial Cells
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells
por: Pittalà, Valeria, et al.
Publicado: (2017)

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach
por: Platania, Chiara B. M., et al.
Publicado: (2015)

Anti‐angiogenic effect of quercetin and its 8‐methyl pentamethyl ether derivative in human microvascular endothelial cells
por: Lupo, Gabriella, et al.
Publicado: (2019)

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease
por: Caruso, Giuseppe, et al.
Publicado: (2021)

Prognostic significance of deregulated microRNAs in uveal melanomas
por: Falzone, Luca, et al.
Publicado: (2019)

Effects of Vitamin D(3) and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration
por: Lazzara, Francesca, et al.
Publicado: (2021)

Caffeine Protects Against Retinal Inflammation
por: Conti, Federica, et al.
Publicado: (2022)

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ(1-42) Oligomers in Mice: A Key Role of Transforming Growth Factor-β1
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2019)

Folate status in type 2 diabetic patients with and without retinopathy
por: Malaguarnera, Giulia, et al.
Publicado: (2015)

Short-and Long-Term Expression of Vegf: A Temporal Regulation of a Key Factor in Diabetic Retinopathy
por: Bucolo, Claudio, et al.
Publicado: (2021)

Homocysteine Serum Levels in Diabetic Patients with Non Proliferative, Proliferative and without Retinopathy
por: Malaguarnera, Giulia, et al.
Publicado: (2014)

Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway
por: Fidilio, Annamaria, et al.
Publicado: (2022)

Lipoprotein(a) Serum Levels in Diabetic Patients with Retinopathy
por: Malaguarnera, Giulia, et al.
Publicado: (2013)

Retinal and Circulating miRNAs in Age-Related Macular Degeneration: An In vivo Animal and Human Study
por: Romano, Giovanni L., et al.
Publicado: (2017)

Gabapentin Modulates HCN4 Channel Voltage-Dependence
por: Tae, Han-Shen, et al.
Publicado: (2017)

Cytosolic and Calcium-Independent Phospholipases A(2) Activation and Prostaglandins E(2) Are Associated with Escherichia coli-Induced Reduction of Insulin Secretion in INS-1E Cells
por: Caporarello, Nunzia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sbq4ueugq5jj0h5hca5ifr89j4