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Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion

The carboxyl-terminus of the type 1 angiotensin II receptor (AT(1A)) regulates receptor activation/deactivation and the amphipathic Helix 8 within the carboxyl-terminus is a high affinity interaction motif for plasma membrane lipids. We have used dual polarisation interferometry (DPI) to examine the...

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Detalles Bibliográficos
Autores principales:	Hirst, Daniel J., Lee, Tzong-Hsien, Pattenden, Leonard K., Thomas, Walter G., Aguilar, Marie-Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378882/ https://www.ncbi.nlm.nih.gov/pubmed/26126083 http://dx.doi.org/10.1038/srep09972

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