Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered mu...

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Detalles Bibliográficos
Autores principales: Chen, Hong-Sen, Hou, Shin-Chen, Jian, Jhih-Wei, Goh, King-Siang, Shen, San-Tai, Lee, Yu-Ching, You, Jhong-Jhe, Peng, Hung-Pin, Kuo, Wen-Chih, Chen, Shui-Tsung, Peng, Ming-Chi, Wang, Andrew H.-J., Yu, Chung-Ming, Chen, Ing-Chien, Tung, Chao-Ping, Chen, Tzu-Han, Ping Chiu, Kuo, Ma, Che, Yuan Wu, Chih, Lin, Sheng-Wei, Yang, An-Suei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378893/
https://www.ncbi.nlm.nih.gov/pubmed/26202883
http://dx.doi.org/10.1038/srep12411

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