Cargando…

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease

δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-β and tau pathology in Alzheimer's disease (AD). Here we report the therapeutic effect of an orally bioactive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhentao, Obianyo, Obiamaka, Dall, Elfriede, Du, Yuhong, Fu, Haian, Liu, Xia, Kang, Seong Su, Song, Mingke, Yu, Shan-Ping, Cabrele, Chiara, Schubert, Mario, Li, Xiaoguang, Wang, Jian-Zhi, Brandstetter, Hans, Ye, Keqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378956/ https://www.ncbi.nlm.nih.gov/pubmed/28345579 http://dx.doi.org/10.1038/ncomms14740

Ejemplares similares

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
por: Zhang, Zhentao, et al.
Publicado: (2015)

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
por: Kang, Seong Su, et al.
Publicado: (2020)

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
por: Wang, Zhi-Hao, et al.
Publicado: (2018)

Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease
por: Wang, Zhi-Hao, et al.
Publicado: (2019)

Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates
por: Zauner, Florian B., et al.
Publicado: (2018)

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies
por: Wang, Zhi-Hao, et al.
Publicado: (2018)

Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase
por: Chen, Chun, et al.
Publicado: (2021)

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
por: Zhang, Zhentao, et al.
Publicado: (2020)

Delta-secretase triggers Alzheimer’s disease pathologies in wild-type hAPP/hMAPT double transgenic mice
por: Wu, Zhourui, et al.
Publicado: (2020)

The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities
por: Dall, Elfriede, et al.
Publicado: (2021)

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
por: Dall, Elfriede, et al.
Publicado: (2020)

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
por: Wang, Zhi-Hao, et al.
Publicado: (2019)

Repression of Alzheimer's beta-Secretase
por: Liao, Francesca-Fang, et al.
Publicado: (2013)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer’s disease-related pathologies in a senescence-accelerated mouse model
por: Wang, Ju, et al.
Publicado: (2021)

FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice
por: Xiong, Jing, et al.
Publicado: (2023)

Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer’s Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves
por: English, Arthur W., et al.
Publicado: (2021)

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease
por: Zhang, Zhentao, et al.
Publicado: (2014)

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies
por: Chen, Guiqin, et al.
Publicado: (2021)

Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity
por: Freier, Regina, et al.
Publicado: (2015)

Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation
por: Elamin, Tasneem, et al.
Publicado: (2022)

β-Secretases, Alzheimer's Disease, and Down Syndrome
por: Webb, Robin L., et al.
Publicado: (2012)

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
por: Tate, Barbara, et al.
Publicado: (2012)

Amylin and Secretases in the Pathology and Treatment of Alzheimer’s Disease
por: Singh, Som, et al.
Publicado: (2022)

The Alzheimer's disease β-secretase enzyme, BACE1
por: Cole, Sarah L, et al.
Publicado: (2007)

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
por: Chávez-Gutiérrez, Lucía, et al.
Publicado: (2012)

Turning the tide on Alzheimer’s disease: modulation of γ-secretase
por: Luo, Joanna E., et al.
Publicado: (2022)

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
por: Mouchlis, Varnavas D., et al.
Publicado: (2020)

Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain**
por: Dall, Elfriede, et al.
Publicado: (2015)

BACE1, the Alzheimer's beta-secretase enzyme, in health and disease
por: Vassar, Robert
Publicado: (2012)

γ-Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?
por: Toyn, Jeremy H., et al.
Publicado: (2013)

BACE1, the Alzheimer’s beta-secretase enzyme, in health and disease
por: Vassar, Robert
Publicado: (2013)

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
por: Maia, Miguel A., et al.
Publicado: (2019)

A promising new γ-secretase modulator for Alzheimer’s disease
por: Dobrowolska Zakaria, Justyna A., et al.
Publicado: (2021)

Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
por: Wolfe, Michael S.
Publicado: (2021)

β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
por: Galeana-Ascencio, Roberto A., et al.
Publicado: (2023)

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
por: Zhu, Bing, et al.
Publicado: (2017)

Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S
por: Soh, Wai Tuck, et al.
Publicado: (2017)

Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy
por: Hinterholzer, Arthur, et al.
Publicado: (2020)

Detecting aspartate isomerization and backbone cleavage after aspartate in intact proteins by NMR spectroscopy
por: Hinterholzer, Arthur, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_49pial81f7nh0q8u93hobklig0