Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

OBJECTIVE(S): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. MATERIALS AND METHODS: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact,...

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Detalles Bibliográficos
Autores principales: Farjah, Gholam Hossein, Salehi, Shadi, Ansari, Mohammad Hasan, Pourheidar, Bagher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2017
Materias:
Short Comunication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378972/
https://www.ncbi.nlm.nih.gov/pubmed/28392907
http://dx.doi.org/10.22038/IJBMS.2017.8364
Descripción
Sumario:OBJECTIVE(S): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. MATERIALS AND METHODS: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. RESULTS: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of motor normal neurons was significantly greater in the high saffron extract group than in the NS and low saffron group (P<0.05). CONCLUSION: These data suggest that a saffron extract may protect spinal cord neurons from I/R injury.

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