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Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, lea...

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Detalles Bibliográficos
Autores principales:	Liu, Zuqiang, Ravindranathan, Roshni, Kalinski, Pawel, Guo, Z. Sheng, Bartlett, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378974/ https://www.ncbi.nlm.nih.gov/pubmed/28345650 http://dx.doi.org/10.1038/ncomms14754

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