Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system

A key challenge in the field of therapeutic viral vector/vaccine manufacturing is maximizing production. For most vector platforms, the ‘benchmark' vector titres are achieved with inert reporter genes. However, expression of therapeutic transgenes can often adversely affect vector titres due to...

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Detalles Bibliográficos
Autores principales: Maunder, H. E., Wright, J., Kolli, B. R., Vieira, C. R., Mkandawire, T. T., Tatoris, S., Kennedy, V., Iqball, S., Devarajan, G., Ellis, S., Lad, Y., Clarkson, N. G., Mitrophanous, K. A., Farley, D. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378976/
https://www.ncbi.nlm.nih.gov/pubmed/28345582
http://dx.doi.org/10.1038/ncomms14834

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