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Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer
Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes g...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379099/ https://www.ncbi.nlm.nih.gov/pubmed/28421114 http://dx.doi.org/10.1155/2017/3456264 |
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author | Singh, Shyam Jha, Hem Chandra |
author_facet | Singh, Shyam Jha, Hem Chandra |
author_sort | Singh, Shyam |
collection | PubMed |
description | Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV. Approximately 180 per hundred thousand population is developing GC along with many gastric abnormalities. This makes GC the third leading cause of cancer-related death worldwide. Although lots of research are carried out individually for EBV and H. pylori, still there are very few reports available on coinfection of both pathogens. Recent studies suggested that EBV and H. pylori coinfection increases the occurrence of GC as well as the early age of GC detection comparing to individual infection. The aim of this review is to present status on coinfection of both pathogens and their association with GC. |
format | Online Article Text |
id | pubmed-5379099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-53790992017-04-18 Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer Singh, Shyam Jha, Hem Chandra J Oncol Review Article Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV. Approximately 180 per hundred thousand population is developing GC along with many gastric abnormalities. This makes GC the third leading cause of cancer-related death worldwide. Although lots of research are carried out individually for EBV and H. pylori, still there are very few reports available on coinfection of both pathogens. Recent studies suggested that EBV and H. pylori coinfection increases the occurrence of GC as well as the early age of GC detection comparing to individual infection. The aim of this review is to present status on coinfection of both pathogens and their association with GC. Hindawi 2017 2017-03-21 /pmc/articles/PMC5379099/ /pubmed/28421114 http://dx.doi.org/10.1155/2017/3456264 Text en Copyright © 2017 Shyam Singh and Hem Chandra Jha. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Singh, Shyam Jha, Hem Chandra Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer |
title | Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer |
title_full | Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer |
title_fullStr | Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer |
title_full_unstemmed | Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer |
title_short | Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer |
title_sort | status of epstein-barr virus coinfection with helicobacter pylori in gastric cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379099/ https://www.ncbi.nlm.nih.gov/pubmed/28421114 http://dx.doi.org/10.1155/2017/3456264 |
work_keys_str_mv | AT singhshyam statusofepsteinbarrviruscoinfectionwithhelicobacterpyloriingastriccancer AT jhahemchandra statusofepsteinbarrviruscoinfectionwithhelicobacterpyloriingastriccancer |