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Inhibition of Cdk5 induces cell death of tumor-initiating cells

BACKGROUND: Tumour-initiating cells (TICs) account for chemoresistance, tumour recurrence and metastasis, and therefore represent a major problem in tumour therapy. However, strategies to address TICs are limited. Recent studies indicate Cdk5 as a promising target for anti-cancer therapy and Cdk5 ha...

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Detalles Bibliográficos
Autores principales:	Mandl, Melanie M, Zhang, Siwei, Ulrich, Melanie, Schmoeckel, Elisa, Mayr, Doris, Vollmar, Angelika M, Liebl, Johanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379151/ https://www.ncbi.nlm.nih.gov/pubmed/28222068 http://dx.doi.org/10.1038/bjc.2017.39

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