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Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement

White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibi...

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Autores principales: Xie, Xian-Ju, Xing, Dan, Wang, Lin, Zhou, Han, Weir, Michael D, Bai, Yu-Xing, Xu, Hockin HK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379158/
https://www.ncbi.nlm.nih.gov/pubmed/27811847
http://dx.doi.org/10.1038/ijos.2016.40
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author Xie, Xian-Ju
Xing, Dan
Wang, Lin
Zhou, Han
Weir, Michael D
Bai, Yu-Xing
Xu, Hockin HK
author_facet Xie, Xian-Ju
Xing, Dan
Wang, Lin
Zhou, Han
Weir, Michael D
Bai, Yu-Xing
Xu, Hockin HK
author_sort Xie, Xian-Ju
collection PubMed
description White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength (SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release (P>0.1). Specimens after one recharge treatment (e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as “1 min 3 times”) exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles (P>0.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times>3 min 2 times>1 min 2 times>6 min 1 time>3 min 1 time>1 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets.
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spelling pubmed-53791582017-04-17 Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement Xie, Xian-Ju Xing, Dan Wang, Lin Zhou, Han Weir, Michael D Bai, Yu-Xing Xu, Hockin HK Int J Oral Sci Original Article White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength (SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release (P>0.1). Specimens after one recharge treatment (e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as “1 min 3 times”) exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles (P>0.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times>3 min 2 times>1 min 2 times>6 min 1 time>3 min 1 time>1 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets. Nature Publishing Group 2017-03 2016-11-04 /pmc/articles/PMC5379158/ /pubmed/27811847 http://dx.doi.org/10.1038/ijos.2016.40 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Xie, Xian-Ju
Xing, Dan
Wang, Lin
Zhou, Han
Weir, Michael D
Bai, Yu-Xing
Xu, Hockin HK
Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
title Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
title_full Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
title_fullStr Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
title_full_unstemmed Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
title_short Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
title_sort novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379158/
https://www.ncbi.nlm.nih.gov/pubmed/27811847
http://dx.doi.org/10.1038/ijos.2016.40
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