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Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance o...

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Autores principales: Huang, Yan, Bornstein, Michael M, Lambrichts, Ivo, Yu, Hai-Yang, Politis, Constantinus, Jacobs, Reinhilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379164/
https://www.ncbi.nlm.nih.gov/pubmed/28282030
http://dx.doi.org/10.1038/ijos.2017.1
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author Huang, Yan
Bornstein, Michael M
Lambrichts, Ivo
Yu, Hai-Yang
Politis, Constantinus
Jacobs, Reinhilde
author_facet Huang, Yan
Bornstein, Michael M
Lambrichts, Ivo
Yu, Hai-Yang
Politis, Constantinus
Jacobs, Reinhilde
author_sort Huang, Yan
collection PubMed
description Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.
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spelling pubmed-53791642017-04-17 Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities Huang, Yan Bornstein, Michael M Lambrichts, Ivo Yu, Hai-Yang Politis, Constantinus Jacobs, Reinhilde Int J Oral Sci Review Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed. Nature Publishing Group 2017-03 2017-03-10 /pmc/articles/PMC5379164/ /pubmed/28282030 http://dx.doi.org/10.1038/ijos.2017.1 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review
Huang, Yan
Bornstein, Michael M
Lambrichts, Ivo
Yu, Hai-Yang
Politis, Constantinus
Jacobs, Reinhilde
Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
title Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
title_full Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
title_fullStr Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
title_full_unstemmed Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
title_short Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
title_sort platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379164/
https://www.ncbi.nlm.nih.gov/pubmed/28282030
http://dx.doi.org/10.1038/ijos.2017.1
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