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Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands

The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less fr...

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Autores principales: Bell, Rob, Duke, Aaron A., Gilmore, Paula E., Page, Deaglan, Bègue, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379192/
https://www.ncbi.nlm.nih.gov/pubmed/24457553
http://dx.doi.org/10.1038/srep03881
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author Bell, Rob
Duke, Aaron A.
Gilmore, Paula E.
Page, Deaglan
Bègue, Laurent
author_facet Bell, Rob
Duke, Aaron A.
Gilmore, Paula E.
Page, Deaglan
Bègue, Laurent
author_sort Bell, Rob
collection PubMed
description The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less frequently. Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75 mg/kg). In the first experiment, we administered the 5-HT(2C) antagonist RS 102221 (0.5, 1.0, and 2.0 mg/kg) and 5-HT(2C) agonist MK-212 (0.25, 0.5 and 0.75 mg/kg); in the second experiment, we administered the 5-HT(3) antagonist Y-25130 (0.1, 1.0 and 3.0 mg/kg) and 5-HT(3) agonist SR 57227A (0.1, 1.0 and 3.0 mg/kg), and in the third experiment, we administered the 5-HT(4) antagonist RS 39604 (0.01, 0.1, 1.0 mg/kg) and 5-HT(4) agonist RS 67333 (0.01, 0.1 and 0.5 mg/kg). The administration of 5-HT(2/3/4) subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures. While little effect was observed from 5-HT(2) and 5-HT(3) agonists, the 5-HT(4) agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produced by the 5-HT(4) antagonist RS 39604. We conclude by discussing the implications of these findings.
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spelling pubmed-53791922017-04-10 Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands Bell, Rob Duke, Aaron A. Gilmore, Paula E. Page, Deaglan Bègue, Laurent Sci Rep Article The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less frequently. Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75 mg/kg). In the first experiment, we administered the 5-HT(2C) antagonist RS 102221 (0.5, 1.0, and 2.0 mg/kg) and 5-HT(2C) agonist MK-212 (0.25, 0.5 and 0.75 mg/kg); in the second experiment, we administered the 5-HT(3) antagonist Y-25130 (0.1, 1.0 and 3.0 mg/kg) and 5-HT(3) agonist SR 57227A (0.1, 1.0 and 3.0 mg/kg), and in the third experiment, we administered the 5-HT(4) antagonist RS 39604 (0.01, 0.1, 1.0 mg/kg) and 5-HT(4) agonist RS 67333 (0.01, 0.1 and 0.5 mg/kg). The administration of 5-HT(2/3/4) subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures. While little effect was observed from 5-HT(2) and 5-HT(3) agonists, the 5-HT(4) agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produced by the 5-HT(4) antagonist RS 39604. We conclude by discussing the implications of these findings. Nature Publishing Group 2014-01-24 /pmc/articles/PMC5379192/ /pubmed/24457553 http://dx.doi.org/10.1038/srep03881 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Article
Bell, Rob
Duke, Aaron A.
Gilmore, Paula E.
Page, Deaglan
Bègue, Laurent
Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
title Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
title_full Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
title_fullStr Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
title_full_unstemmed Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
title_short Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
title_sort anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-ht(2)/5-ht(3)/5-ht(4) ligands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379192/
https://www.ncbi.nlm.nih.gov/pubmed/24457553
http://dx.doi.org/10.1038/srep03881
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