Cargando…
Breast tumor subgroups reveal diverse clinical prognostic power
Predicting the outcome of cancer therapies using molecular features and clinical observations is a key goal of cancer biology, which has been addressed comprehensively using whole patient datasets without considering the effect of tumor heterogeneity. We hypothesized that molecular features and clin...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379255/ https://www.ncbi.nlm.nih.gov/pubmed/24499868 http://dx.doi.org/10.1038/srep04002 |
_version_ | 1782519571979173888 |
---|---|
author | Liu, Zhaoqi Zhang, Xiang-Sun Zhang, Shihua |
author_facet | Liu, Zhaoqi Zhang, Xiang-Sun Zhang, Shihua |
author_sort | Liu, Zhaoqi |
collection | PubMed |
description | Predicting the outcome of cancer therapies using molecular features and clinical observations is a key goal of cancer biology, which has been addressed comprehensively using whole patient datasets without considering the effect of tumor heterogeneity. We hypothesized that molecular features and clinical observations have different prognostic abilities for different cancer subtypes, and made a systematic study using both clinical observations and gene expression data. This analysis revealed that (1) gene expression profiles and clinical features show different prognostic power for the five breast cancer subtypes; (2) gene expression data of the normal-like subgroup contains more valuable prognostic information and survival associated contexts than the other subtypes, and the patient survival time of the normal-like subtype is more predictable based on the gene expression profiles; and (3) the prognostic power of many previously reported breast cancer gene signatures increased in the normal-like subtype and reduced in the other subtypes compared with that in the whole sample set. |
format | Online Article Text |
id | pubmed-5379255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53792552017-04-10 Breast tumor subgroups reveal diverse clinical prognostic power Liu, Zhaoqi Zhang, Xiang-Sun Zhang, Shihua Sci Rep Article Predicting the outcome of cancer therapies using molecular features and clinical observations is a key goal of cancer biology, which has been addressed comprehensively using whole patient datasets without considering the effect of tumor heterogeneity. We hypothesized that molecular features and clinical observations have different prognostic abilities for different cancer subtypes, and made a systematic study using both clinical observations and gene expression data. This analysis revealed that (1) gene expression profiles and clinical features show different prognostic power for the five breast cancer subtypes; (2) gene expression data of the normal-like subgroup contains more valuable prognostic information and survival associated contexts than the other subtypes, and the patient survival time of the normal-like subtype is more predictable based on the gene expression profiles; and (3) the prognostic power of many previously reported breast cancer gene signatures increased in the normal-like subtype and reduced in the other subtypes compared with that in the whole sample set. Nature Publishing Group 2014-02-06 /pmc/articles/PMC5379255/ /pubmed/24499868 http://dx.doi.org/10.1038/srep04002 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Liu, Zhaoqi Zhang, Xiang-Sun Zhang, Shihua Breast tumor subgroups reveal diverse clinical prognostic power |
title | Breast tumor subgroups reveal diverse clinical prognostic power |
title_full | Breast tumor subgroups reveal diverse clinical prognostic power |
title_fullStr | Breast tumor subgroups reveal diverse clinical prognostic power |
title_full_unstemmed | Breast tumor subgroups reveal diverse clinical prognostic power |
title_short | Breast tumor subgroups reveal diverse clinical prognostic power |
title_sort | breast tumor subgroups reveal diverse clinical prognostic power |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379255/ https://www.ncbi.nlm.nih.gov/pubmed/24499868 http://dx.doi.org/10.1038/srep04002 |
work_keys_str_mv | AT liuzhaoqi breasttumorsubgroupsrevealdiverseclinicalprognosticpower AT zhangxiangsun breasttumorsubgroupsrevealdiverseclinicalprognosticpower AT zhangshihua breasttumorsubgroupsrevealdiverseclinicalprognosticpower |