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Epidemiological characteristics of primary spinal osseous tumors in Eastern China

BACKGROUND: Primary spinal osseous tumors are rare, yet they represent a difficult treatment paradigm because of the complexities of tumor resection and significant resistance to chemotherapy and radiation therapy. The geographic distribution of primary spinal osseous tumors throughout the world app...

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Autores principales: Zhou, Zhenhua, Wang, Xudong, Wu, Zhipeng, Huang, Wending, Xiao, Jianru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379532/
https://www.ncbi.nlm.nih.gov/pubmed/28376922
http://dx.doi.org/10.1186/s12957-017-1136-1
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author Zhou, Zhenhua
Wang, Xudong
Wu, Zhipeng
Huang, Wending
Xiao, Jianru
author_facet Zhou, Zhenhua
Wang, Xudong
Wu, Zhipeng
Huang, Wending
Xiao, Jianru
author_sort Zhou, Zhenhua
collection PubMed
description BACKGROUND: Primary spinal osseous tumors are rare, yet they represent a difficult treatment paradigm because of the complexities of tumor resection and significant resistance to chemotherapy and radiation therapy. The geographic distribution of primary spinal osseous tumors throughout the world appears to be quite variable, with a very low incidence reported in Asian countries. METHODS: Data on 1209 cases of primary spinal osseous malignant and benign tumor cases diagnosed during the 20-year period of 1995 through 2015 in eastern China were analyzed. RESULTS: In 780 cases (64.5%), the lesion was benign and in 429 (35.5%) was malignant. The commonest primary malignant tumors were chordoma (9.8% of all cases) followed by plasma cell myeloma (8.5% of all cases). The most common benign tumor was hemangioma (28.1% of all cases) followed by giant cell tumor of bone (15.7% of all cases) and osteoblastoma (4.4% of all cases). The benign tumors affected men in 33.8% of cases and women in 30.7% of cases, the malignant tumors affected men in 23.7% of cases and women in 11.8%. The mean age (mean ± SD) in the benign group was 34.7 ± 19.8 years and in the malignant group was 47.4 ± 16.5 years. Related symptoms were pain (54.4%), radiculopathy (12.9%), cord compression (9.2%), mass (5.7%), pathological fracture (4.7%), deformity (2.1%), and weight loss (1.9%). The anatomical locations included almost every vertebra of the spine. The thoracic spine (38.1%) was the most common location of the tumors, followed by the cervical spine (27.4%) and lumbar spine (18.4%). CONCLUSIONS: Compared with other similar series reported in the literature from the other countries, our results obtained in a developing country were different in some degree. This large series of primary spinal osseous tumors may reflect fairly well their real incidence and provide a sufficiently detailed perspective on epidemiologic studies of primary spinal osseous tumors in eastern China. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-017-1136-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-53795322017-04-07 Epidemiological characteristics of primary spinal osseous tumors in Eastern China Zhou, Zhenhua Wang, Xudong Wu, Zhipeng Huang, Wending Xiao, Jianru World J Surg Oncol Research BACKGROUND: Primary spinal osseous tumors are rare, yet they represent a difficult treatment paradigm because of the complexities of tumor resection and significant resistance to chemotherapy and radiation therapy. The geographic distribution of primary spinal osseous tumors throughout the world appears to be quite variable, with a very low incidence reported in Asian countries. METHODS: Data on 1209 cases of primary spinal osseous malignant and benign tumor cases diagnosed during the 20-year period of 1995 through 2015 in eastern China were analyzed. RESULTS: In 780 cases (64.5%), the lesion was benign and in 429 (35.5%) was malignant. The commonest primary malignant tumors were chordoma (9.8% of all cases) followed by plasma cell myeloma (8.5% of all cases). The most common benign tumor was hemangioma (28.1% of all cases) followed by giant cell tumor of bone (15.7% of all cases) and osteoblastoma (4.4% of all cases). The benign tumors affected men in 33.8% of cases and women in 30.7% of cases, the malignant tumors affected men in 23.7% of cases and women in 11.8%. The mean age (mean ± SD) in the benign group was 34.7 ± 19.8 years and in the malignant group was 47.4 ± 16.5 years. Related symptoms were pain (54.4%), radiculopathy (12.9%), cord compression (9.2%), mass (5.7%), pathological fracture (4.7%), deformity (2.1%), and weight loss (1.9%). The anatomical locations included almost every vertebra of the spine. The thoracic spine (38.1%) was the most common location of the tumors, followed by the cervical spine (27.4%) and lumbar spine (18.4%). CONCLUSIONS: Compared with other similar series reported in the literature from the other countries, our results obtained in a developing country were different in some degree. This large series of primary spinal osseous tumors may reflect fairly well their real incidence and provide a sufficiently detailed perspective on epidemiologic studies of primary spinal osseous tumors in eastern China. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-017-1136-1) contains supplementary material, which is available to authorized users. BioMed Central 2017-04-04 /pmc/articles/PMC5379532/ /pubmed/28376922 http://dx.doi.org/10.1186/s12957-017-1136-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhou, Zhenhua
Wang, Xudong
Wu, Zhipeng
Huang, Wending
Xiao, Jianru
Epidemiological characteristics of primary spinal osseous tumors in Eastern China
title Epidemiological characteristics of primary spinal osseous tumors in Eastern China
title_full Epidemiological characteristics of primary spinal osseous tumors in Eastern China
title_fullStr Epidemiological characteristics of primary spinal osseous tumors in Eastern China
title_full_unstemmed Epidemiological characteristics of primary spinal osseous tumors in Eastern China
title_short Epidemiological characteristics of primary spinal osseous tumors in Eastern China
title_sort epidemiological characteristics of primary spinal osseous tumors in eastern china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379532/
https://www.ncbi.nlm.nih.gov/pubmed/28376922
http://dx.doi.org/10.1186/s12957-017-1136-1
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