Noninvasive Bioluminescence Imaging of AKT Kinase Activity in Subcutaneous and Orthotopic NSCLC Xenografts: Correlation of AKT Activity with Tumor Growth Kinetics()

Aberrant signaling through the AKT kinase mediates oncogenic phenotypes including cell proliferation, survival, and therapeutic resistance. Here, we utilize a bioluminescence reporter for AKT kinase activity (BAR) to noninvasively assess the therapeutic efficacy of the EGFR inhibitor erlotinib in KR...

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Detalles Bibliográficos
Autores principales: Suchowski, Karina, Pöschinger, Thomas, Rehemtulla, Alnawaz, Stürzl, Michael, Scheuer, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379573/
https://www.ncbi.nlm.nih.gov/pubmed/28285180
http://dx.doi.org/10.1016/j.neo.2017.02.005

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