Cargando…

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Xiaomeng, Gao, Xia, Yao, Zhi, Xu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379622/
https://www.ncbi.nlm.nih.gov/pubmed/28372564
http://dx.doi.org/10.1186/s12944-017-0446-1
_version_ 1782519642434043904
author Feng, Xiaomeng
Gao, Xia
Yao, Zhi
Xu, Yuan
author_facet Feng, Xiaomeng
Gao, Xia
Yao, Zhi
Xu, Yuan
author_sort Feng, Xiaomeng
collection PubMed
description BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potential association between apoA-I levels and insulin resistance in patients with impaired glucose tolerance (IGT) and the possible link between apoA-I and IGT. METHODS: This study evaluated a cross-sectional study of 108 participants with impaired glucose tolerance (IGT group) and 84 controls (control group). ApoA-I and clinical characteristics were measured, and a homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: The IGT group exhibited significantly lower apoA-I and higher HOMA-IR levels than the control group (apoA-I: 1.37 ± 0.36 vs 1.57 ± 0.39 g/L; HOMA-IR: 4.21 ± 1.56 vs 2.15 ± 0.99; P < 0.001 for both). ApoA-I was negatively correlated with HOMA-IR in both the IGT and control groups (IGT group: r = −0.269, P = 0.005; control group: r = −0.262, P = 0.016). Multiple stepwise regression analysis showed that low apoA-I levels (β = −1.470, P = 0.002) were independently correlated with high HOMA-IR levels in the IGT group. Moreover, logistic regression analysis identified that low apoA-I was an independent influencing factor for IGT (β = −1.170, OR = 0.310, P = 0.007). CONCLUSIONS: ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance. These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT.
format Online
Article
Text
id pubmed-5379622
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-53796222017-04-07 Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study Feng, Xiaomeng Gao, Xia Yao, Zhi Xu, Yuan Lipids Health Dis Research BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potential association between apoA-I levels and insulin resistance in patients with impaired glucose tolerance (IGT) and the possible link between apoA-I and IGT. METHODS: This study evaluated a cross-sectional study of 108 participants with impaired glucose tolerance (IGT group) and 84 controls (control group). ApoA-I and clinical characteristics were measured, and a homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: The IGT group exhibited significantly lower apoA-I and higher HOMA-IR levels than the control group (apoA-I: 1.37 ± 0.36 vs 1.57 ± 0.39 g/L; HOMA-IR: 4.21 ± 1.56 vs 2.15 ± 0.99; P < 0.001 for both). ApoA-I was negatively correlated with HOMA-IR in both the IGT and control groups (IGT group: r = −0.269, P = 0.005; control group: r = −0.262, P = 0.016). Multiple stepwise regression analysis showed that low apoA-I levels (β = −1.470, P = 0.002) were independently correlated with high HOMA-IR levels in the IGT group. Moreover, logistic regression analysis identified that low apoA-I was an independent influencing factor for IGT (β = −1.170, OR = 0.310, P = 0.007). CONCLUSIONS: ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance. These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT. BioMed Central 2017-04-04 /pmc/articles/PMC5379622/ /pubmed/28372564 http://dx.doi.org/10.1186/s12944-017-0446-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Feng, Xiaomeng
Gao, Xia
Yao, Zhi
Xu, Yuan
Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
title Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
title_full Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
title_fullStr Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
title_full_unstemmed Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
title_short Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
title_sort low apoa-i is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379622/
https://www.ncbi.nlm.nih.gov/pubmed/28372564
http://dx.doi.org/10.1186/s12944-017-0446-1
work_keys_str_mv AT fengxiaomeng lowapoaiisassociatedwithinsulinresistanceinpatientswithimpairedglucosetoleranceacrosssectionalstudy
AT gaoxia lowapoaiisassociatedwithinsulinresistanceinpatientswithimpairedglucosetoleranceacrosssectionalstudy
AT yaozhi lowapoaiisassociatedwithinsulinresistanceinpatientswithimpairedglucosetoleranceacrosssectionalstudy
AT xuyuan lowapoaiisassociatedwithinsulinresistanceinpatientswithimpairedglucosetoleranceacrosssectionalstudy