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Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study
BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potenti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379622/ https://www.ncbi.nlm.nih.gov/pubmed/28372564 http://dx.doi.org/10.1186/s12944-017-0446-1 |
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author | Feng, Xiaomeng Gao, Xia Yao, Zhi Xu, Yuan |
author_facet | Feng, Xiaomeng Gao, Xia Yao, Zhi Xu, Yuan |
author_sort | Feng, Xiaomeng |
collection | PubMed |
description | BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potential association between apoA-I levels and insulin resistance in patients with impaired glucose tolerance (IGT) and the possible link between apoA-I and IGT. METHODS: This study evaluated a cross-sectional study of 108 participants with impaired glucose tolerance (IGT group) and 84 controls (control group). ApoA-I and clinical characteristics were measured, and a homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: The IGT group exhibited significantly lower apoA-I and higher HOMA-IR levels than the control group (apoA-I: 1.37 ± 0.36 vs 1.57 ± 0.39 g/L; HOMA-IR: 4.21 ± 1.56 vs 2.15 ± 0.99; P < 0.001 for both). ApoA-I was negatively correlated with HOMA-IR in both the IGT and control groups (IGT group: r = −0.269, P = 0.005; control group: r = −0.262, P = 0.016). Multiple stepwise regression analysis showed that low apoA-I levels (β = −1.470, P = 0.002) were independently correlated with high HOMA-IR levels in the IGT group. Moreover, logistic regression analysis identified that low apoA-I was an independent influencing factor for IGT (β = −1.170, OR = 0.310, P = 0.007). CONCLUSIONS: ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance. These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT. |
format | Online Article Text |
id | pubmed-5379622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53796222017-04-07 Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study Feng, Xiaomeng Gao, Xia Yao, Zhi Xu, Yuan Lipids Health Dis Research BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potential association between apoA-I levels and insulin resistance in patients with impaired glucose tolerance (IGT) and the possible link between apoA-I and IGT. METHODS: This study evaluated a cross-sectional study of 108 participants with impaired glucose tolerance (IGT group) and 84 controls (control group). ApoA-I and clinical characteristics were measured, and a homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: The IGT group exhibited significantly lower apoA-I and higher HOMA-IR levels than the control group (apoA-I: 1.37 ± 0.36 vs 1.57 ± 0.39 g/L; HOMA-IR: 4.21 ± 1.56 vs 2.15 ± 0.99; P < 0.001 for both). ApoA-I was negatively correlated with HOMA-IR in both the IGT and control groups (IGT group: r = −0.269, P = 0.005; control group: r = −0.262, P = 0.016). Multiple stepwise regression analysis showed that low apoA-I levels (β = −1.470, P = 0.002) were independently correlated with high HOMA-IR levels in the IGT group. Moreover, logistic regression analysis identified that low apoA-I was an independent influencing factor for IGT (β = −1.170, OR = 0.310, P = 0.007). CONCLUSIONS: ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance. These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT. BioMed Central 2017-04-04 /pmc/articles/PMC5379622/ /pubmed/28372564 http://dx.doi.org/10.1186/s12944-017-0446-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Feng, Xiaomeng Gao, Xia Yao, Zhi Xu, Yuan Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
title | Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
title_full | Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
title_fullStr | Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
title_full_unstemmed | Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
title_short | Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
title_sort | low apoa-i is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379622/ https://www.ncbi.nlm.nih.gov/pubmed/28372564 http://dx.doi.org/10.1186/s12944-017-0446-1 |
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