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Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants
Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding sites and mechanism of block remain unclear. Her...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379917/ https://www.ncbi.nlm.nih.gov/pubmed/28258204 http://dx.doi.org/10.1085/jgp.201611668 |