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Structure of the RZZ complex and molecular basis of its interaction with Spindly
Kinetochores are macromolecular assemblies that connect chromosomes to spindle microtubules (MTs) during mitosis. The metazoan-specific ≈800-kD ROD–Zwilch–ZW10 (RZZ) complex builds a fibrous corona that assembles on mitotic kinetochores before MT attachment to promote chromosome alignment and robust...
Autores principales: | Mosalaganti, Shyamal, Keller, Jenny, Altenfeld, Anika, Winzker, Michael, Rombaut, Pascaline, Saur, Michael, Petrovic, Arsen, Wehenkel, Annemarie, Wohlgemuth, Sabine, Müller, Franziska, Maffini, Stefano, Bange, Tanja, Herzog, Franz, Waldmann, Herbert, Raunser, Stefan, Musacchio, Andrea |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379955/ https://www.ncbi.nlm.nih.gov/pubmed/28320825 http://dx.doi.org/10.1083/jcb.201611060 |
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