Tensin links energy metabolism to extracellular matrix assembly

The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201609066) report that the metabolic sensor adenosine monophosphate–activa...

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Detalles Bibliográficos
Autores principales: Dornier, Emmanuel, Norman, Jim C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379960/
https://www.ncbi.nlm.nih.gov/pubmed/28325807
http://dx.doi.org/10.1083/jcb.201702025
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author Dornier, Emmanuel
Norman, Jim C.
author_facet Dornier, Emmanuel
Norman, Jim C.
author_sort Dornier, Emmanuel
collection PubMed
description The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201609066) report that the metabolic sensor adenosine monophosphate–activated protein kinase influences tensin production to regulate α5β1-integrin and fibrillar adhesion assembly and thus reveal an important connection between energy metabolism and ECM assembly.
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spelling pubmed-53799602017-10-03 Tensin links energy metabolism to extracellular matrix assembly Dornier, Emmanuel Norman, Jim C. J Cell Biol Commentary The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201609066) report that the metabolic sensor adenosine monophosphate–activated protein kinase influences tensin production to regulate α5β1-integrin and fibrillar adhesion assembly and thus reveal an important connection between energy metabolism and ECM assembly. The Rockefeller University Press 2017-04-03 /pmc/articles/PMC5379960/ /pubmed/28325807 http://dx.doi.org/10.1083/jcb.201702025 Text en © 2017 Dornier and Norman http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Dornier, Emmanuel
Norman, Jim C.
Tensin links energy metabolism to extracellular matrix assembly
title Tensin links energy metabolism to extracellular matrix assembly
title_full Tensin links energy metabolism to extracellular matrix assembly
title_fullStr Tensin links energy metabolism to extracellular matrix assembly
title_full_unstemmed Tensin links energy metabolism to extracellular matrix assembly
title_short Tensin links energy metabolism to extracellular matrix assembly
title_sort tensin links energy metabolism to extracellular matrix assembly
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379960/
https://www.ncbi.nlm.nih.gov/pubmed/28325807
http://dx.doi.org/10.1083/jcb.201702025
work_keys_str_mv AT dornieremmanuel tensinlinksenergymetabolismtoextracellularmatrixassembly
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