Macrophages: micromanagers of antagonistic signaling nanoclusters

How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, aft...

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Detalles Bibliográficos
Autores principales: Eggeling, Christian, Davis, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379961/
https://www.ncbi.nlm.nih.gov/pubmed/28330938
http://dx.doi.org/10.1083/jcb.201702028
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author Eggeling, Christian
Davis, Simon J.
author_facet Eggeling, Christian
Davis, Simon J.
author_sort Eggeling, Christian
collection PubMed
description How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.
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spelling pubmed-53799612017-10-03 Macrophages: micromanagers of antagonistic signaling nanoclusters Eggeling, Christian Davis, Simon J. J Cell Biol Commentary How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells. The Rockefeller University Press 2017-04-03 /pmc/articles/PMC5379961/ /pubmed/28330938 http://dx.doi.org/10.1083/jcb.201702028 Text en © 2017 Eggeling and Davis http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Eggeling, Christian
Davis, Simon J.
Macrophages: micromanagers of antagonistic signaling nanoclusters
title Macrophages: micromanagers of antagonistic signaling nanoclusters
title_full Macrophages: micromanagers of antagonistic signaling nanoclusters
title_fullStr Macrophages: micromanagers of antagonistic signaling nanoclusters
title_full_unstemmed Macrophages: micromanagers of antagonistic signaling nanoclusters
title_short Macrophages: micromanagers of antagonistic signaling nanoclusters
title_sort macrophages: micromanagers of antagonistic signaling nanoclusters
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379961/
https://www.ncbi.nlm.nih.gov/pubmed/28330938
http://dx.doi.org/10.1083/jcb.201702028
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