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Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway

Transient suppression of B cell function often accompanies acute viral infection. However, the molecular signaling circuitry that enforces this hyporesponsiveness is undefined. In this study, experiments identify up-regulation of the inositol phosphatase PTEN (phosphatase and tensin homolog) as prim...

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Detalles Bibliográficos
Autores principales:	Getahun, Andrew, Wemlinger, Scott M., Rudra, Pratyaydipta, Santiago, Mario L., van Dyk, Linda F., Cambier, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379973/ https://www.ncbi.nlm.nih.gov/pubmed/28341640 http://dx.doi.org/10.1084/jem.20160972

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