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Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and R...

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Detalles Bibliográficos
Autores principales:	Hu, Ming-Ming, Liao, Chen-Yang, Yang, Qing, Xie, Xue-Qin, Shu, Hong-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379974/ https://www.ncbi.nlm.nih.gov/pubmed/28250012 http://dx.doi.org/10.1084/jem.20161015

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