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Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Recent genetic evidence supports a link between microglia and the complement system in Alzheimer’s disease (AD). In this study, we uncovered a novel role for the microglial complement receptor 3 (CR3) in the regulation of soluble β-amyloid (Aβ) clearance independent of phagocytosis. Unexpectedly, ab...

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Detalles Bibliográficos
Autores principales:	Czirr, Eva, Castello, Nicholas A., Mosher, Kira I., Castellano, Joseph M., Hinkson, Izumi V., Lucin, Kurt M., Baeza-Raja, Bernat, Ryu, Jae Kyu, Li, Lulin, Farina, Sasha N., Belichenko, Nadia P., Longo, Frank M., Akassoglou, Katerina, Britschgi, Markus, Cirrito, John R., Wyss-Coray, Tony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379986/ https://www.ncbi.nlm.nih.gov/pubmed/28298456 http://dx.doi.org/10.1084/jem.20162011

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