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Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins

We developed a large-scale, unbiased analysis method to measure how functional variations in importin (IMP) α2, IMPα4 and IMPα6 each influence PSPC1 and SFPQ nuclear accumulation and their localization to paraspeckles. This addresses the hypothesis that individual IMP protein activities determine ca...

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Detalles Bibliográficos
Autores principales:	Major, Andrew T., Miyamoto, Yoichi, Lo, Camden Y., Jans, David A., Loveland, Kate L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379994/ https://www.ncbi.nlm.nih.gov/pubmed/28240251 http://dx.doi.org/10.1038/srep43323

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