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Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis

N-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3) is a Class I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N-acetyl-D-mannosamine (ManNAc). Due to the equilibrium favoring Neu5Ac cleavage, the enzyme catalyzes the rate-limiting s...

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Detalles Bibliográficos
Autores principales:	Ji, Wenyan, Sun, Wujin, Feng, Jinmei, Song, Tianshun, Zhang, Dalu, Ouyang, Pingkai, Gu, Zhen, Xie, Jingjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380162/ https://www.ncbi.nlm.nih.gov/pubmed/25799411 http://dx.doi.org/10.1038/srep09341

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