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Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy

BACKGROUND: Thromboelastography (TEG) has been utilized for the guidance of blood component therapy (BCT). We aimed to investigate the association between emergent TEG-guided BCT and clinical outcomes in patients with traumatic abdominal solid organ (liver and/or spleen) injuries. METHODS: A single...

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Autores principales: Wang, Hao, Robinson, Richard D., Phillips, Jessica L., Ryon, Andrew, Simpson, Scott, Ford, Jonathan R., Umejiego, Johnbosco, Duane, Therese M., Putty, Bradley, Zenarosa, Nestor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380177/
https://www.ncbi.nlm.nih.gov/pubmed/28392864
http://dx.doi.org/10.14740/jocmr3005w
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author Wang, Hao
Robinson, Richard D.
Phillips, Jessica L.
Ryon, Andrew
Simpson, Scott
Ford, Jonathan R.
Umejiego, Johnbosco
Duane, Therese M.
Putty, Bradley
Zenarosa, Nestor R.
author_facet Wang, Hao
Robinson, Richard D.
Phillips, Jessica L.
Ryon, Andrew
Simpson, Scott
Ford, Jonathan R.
Umejiego, Johnbosco
Duane, Therese M.
Putty, Bradley
Zenarosa, Nestor R.
author_sort Wang, Hao
collection PubMed
description BACKGROUND: Thromboelastography (TEG) has been utilized for the guidance of blood component therapy (BCT). We aimed to investigate the association between emergent TEG-guided BCT and clinical outcomes in patients with traumatic abdominal solid organ (liver and/or spleen) injuries. METHODS: A single center retrospective study of patients who sustained traumatic liver and/or spleen injuries receiving emergent BCT was conducted. TEG was ordered in all these patients. Patient demographics, general injury information, outcomes, BCT, and TEG parameters were analyzed and compared in patients receiving TEG-guided BCT versus those without. RESULTS: A total of 166 patients were enrolled, of whom 52% (86/166) received TEG-guided BCT. A mortality of 12% was noted among patients with TEG-guided BCT when compared with 19% of mortality in patients with non-TEG-guided BCT (P > 0.05). An average of 4 units of packed red blood cell (PRBC) was received in patients with TEG-guided BCT when compared to an average of 9 units of PRBC received in non-TEG-guided BCT patients (P < 0.01). A longer hospital length of stay (LOS, 19 ± 16 days) was found among non-TEG-guided BCT patients when compared to the TEG-guided BCT group (14 ± 12 days, P < 0.05). TEG-guided BCT showed as an independent factor associated with hospital LOS after other variables were adjusted (coefficiency: 5.44, 95% confidence interval: 0.69 - 10.18). CONCLUSIONS: Traumatic abdominal solid organ injury patients receiving blood transfusions might benefit from TEG-guided BCT as indicated by less blood products needed and less hospitalization stay among the cohort.
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spelling pubmed-53801772017-04-07 Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy Wang, Hao Robinson, Richard D. Phillips, Jessica L. Ryon, Andrew Simpson, Scott Ford, Jonathan R. Umejiego, Johnbosco Duane, Therese M. Putty, Bradley Zenarosa, Nestor R. J Clin Med Res Original Article BACKGROUND: Thromboelastography (TEG) has been utilized for the guidance of blood component therapy (BCT). We aimed to investigate the association between emergent TEG-guided BCT and clinical outcomes in patients with traumatic abdominal solid organ (liver and/or spleen) injuries. METHODS: A single center retrospective study of patients who sustained traumatic liver and/or spleen injuries receiving emergent BCT was conducted. TEG was ordered in all these patients. Patient demographics, general injury information, outcomes, BCT, and TEG parameters were analyzed and compared in patients receiving TEG-guided BCT versus those without. RESULTS: A total of 166 patients were enrolled, of whom 52% (86/166) received TEG-guided BCT. A mortality of 12% was noted among patients with TEG-guided BCT when compared with 19% of mortality in patients with non-TEG-guided BCT (P > 0.05). An average of 4 units of packed red blood cell (PRBC) was received in patients with TEG-guided BCT when compared to an average of 9 units of PRBC received in non-TEG-guided BCT patients (P < 0.01). A longer hospital length of stay (LOS, 19 ± 16 days) was found among non-TEG-guided BCT patients when compared to the TEG-guided BCT group (14 ± 12 days, P < 0.05). TEG-guided BCT showed as an independent factor associated with hospital LOS after other variables were adjusted (coefficiency: 5.44, 95% confidence interval: 0.69 - 10.18). CONCLUSIONS: Traumatic abdominal solid organ injury patients receiving blood transfusions might benefit from TEG-guided BCT as indicated by less blood products needed and less hospitalization stay among the cohort. Elmer Press 2017-05 2017-04-01 /pmc/articles/PMC5380177/ /pubmed/28392864 http://dx.doi.org/10.14740/jocmr3005w Text en Copyright 2017, Wang et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wang, Hao
Robinson, Richard D.
Phillips, Jessica L.
Ryon, Andrew
Simpson, Scott
Ford, Jonathan R.
Umejiego, Johnbosco
Duane, Therese M.
Putty, Bradley
Zenarosa, Nestor R.
Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy
title Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy
title_full Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy
title_fullStr Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy
title_full_unstemmed Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy
title_short Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy
title_sort traumatic abdominal solid organ injury patients might benefit from thromboelastography-guided blood component therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380177/
https://www.ncbi.nlm.nih.gov/pubmed/28392864
http://dx.doi.org/10.14740/jocmr3005w
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