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Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients

BACKGROUND: The most common cause of heart failure (HF) is ischemic heart disease (IHD). Evaluation of IHD with non-invasive examinations is useful for the treatment of HF, and cardio-ankle vascular index (CAVI) is a good parameter for detecting systemic arteriosclerosis. However, the relationship b...

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Autores principales: Kiuchi, Shunsuke, Hisatake, Shinji, Kabuki, Takayuki, Oka, Takashi, Dobashi, Shintaro, Fujii, Takahiro, Ikeda, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380178/
https://www.ncbi.nlm.nih.gov/pubmed/28392865
http://dx.doi.org/10.14740/jocmr2994w
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author Kiuchi, Shunsuke
Hisatake, Shinji
Kabuki, Takayuki
Oka, Takashi
Dobashi, Shintaro
Fujii, Takahiro
Ikeda, Takanori
author_facet Kiuchi, Shunsuke
Hisatake, Shinji
Kabuki, Takayuki
Oka, Takashi
Dobashi, Shintaro
Fujii, Takahiro
Ikeda, Takanori
author_sort Kiuchi, Shunsuke
collection PubMed
description BACKGROUND: The most common cause of heart failure (HF) is ischemic heart disease (IHD). Evaluation of IHD with non-invasive examinations is useful for the treatment of HF, and cardio-ankle vascular index (CAVI) is a good parameter for detecting systemic arteriosclerosis. However, the relationship between IHD and CAVI in acute HF (AHF) patients is still unclear. Therefore, we investigated the effect of non-invasive examinations, including CAVI to detect IHD. METHODS: We studied 53 consecutive patients (average age of 66.5 ± 10.9 years old, 36 males) with AHF from January 2009 to December 2012. These patients were classified into the IHD group (n = 19) and non-IHD group (n = 34) according to the coronary artery angiography results. We evaluated the vital signs, laboratory findings and CAVI. RESULTS: According to the laboratory findings, the C-reactive protein (CRP) in IHD group was significantly higher than non-IHD group (1.5 ± 2.1 mg/dL vs. 0.4 ± 0.4 mg/dL, P = 0.002). CAVI in IHD group was significantly higher than non-IHD group (9.58 ± 1.73 vs. 7.83 ± 1.86, P < 0.001). In the receiver operating characteristic (ROC) curve for discriminating the probability of IHD, the cut-off point of the CRP plus CAVI was 9.00. At that cut-off point, the sensitivity and the specificity were 69.7% and 89.5%, respectively. The mean area under the ROC curve (AUC) defined by the CRP plus CAVI was the greatest at all parameters. CONCLUSION: The CRP and CAVI were useful parameters for the identification of IHD in patients with AHF.
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spelling pubmed-53801782017-04-07 Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients Kiuchi, Shunsuke Hisatake, Shinji Kabuki, Takayuki Oka, Takashi Dobashi, Shintaro Fujii, Takahiro Ikeda, Takanori J Clin Med Res Original Article BACKGROUND: The most common cause of heart failure (HF) is ischemic heart disease (IHD). Evaluation of IHD with non-invasive examinations is useful for the treatment of HF, and cardio-ankle vascular index (CAVI) is a good parameter for detecting systemic arteriosclerosis. However, the relationship between IHD and CAVI in acute HF (AHF) patients is still unclear. Therefore, we investigated the effect of non-invasive examinations, including CAVI to detect IHD. METHODS: We studied 53 consecutive patients (average age of 66.5 ± 10.9 years old, 36 males) with AHF from January 2009 to December 2012. These patients were classified into the IHD group (n = 19) and non-IHD group (n = 34) according to the coronary artery angiography results. We evaluated the vital signs, laboratory findings and CAVI. RESULTS: According to the laboratory findings, the C-reactive protein (CRP) in IHD group was significantly higher than non-IHD group (1.5 ± 2.1 mg/dL vs. 0.4 ± 0.4 mg/dL, P = 0.002). CAVI in IHD group was significantly higher than non-IHD group (9.58 ± 1.73 vs. 7.83 ± 1.86, P < 0.001). In the receiver operating characteristic (ROC) curve for discriminating the probability of IHD, the cut-off point of the CRP plus CAVI was 9.00. At that cut-off point, the sensitivity and the specificity were 69.7% and 89.5%, respectively. The mean area under the ROC curve (AUC) defined by the CRP plus CAVI was the greatest at all parameters. CONCLUSION: The CRP and CAVI were useful parameters for the identification of IHD in patients with AHF. Elmer Press 2017-05 2017-04-01 /pmc/articles/PMC5380178/ /pubmed/28392865 http://dx.doi.org/10.14740/jocmr2994w Text en Copyright 2017, Kiuchi et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kiuchi, Shunsuke
Hisatake, Shinji
Kabuki, Takayuki
Oka, Takashi
Dobashi, Shintaro
Fujii, Takahiro
Ikeda, Takanori
Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients
title Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients
title_full Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients
title_fullStr Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients
title_full_unstemmed Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients
title_short Cardio-Ankle Vascular Index and C-Reactive Protein Are Useful Parameters for Identification of Ischemic Heart Disease in Acute Heart Failure Patients
title_sort cardio-ankle vascular index and c-reactive protein are useful parameters for identification of ischemic heart disease in acute heart failure patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380178/
https://www.ncbi.nlm.nih.gov/pubmed/28392865
http://dx.doi.org/10.14740/jocmr2994w
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