Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses

Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise...

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Detalles Bibliográficos
Autores principales: White, Michael, Amino, Rogerio, Mueller, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380217/
https://www.ncbi.nlm.nih.gov/pubmed/28077251
http://dx.doi.org/10.1016/j.pt.2016.12.011
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author White, Michael
Amino, Rogerio
Mueller, Ivo
author_facet White, Michael
Amino, Rogerio
Mueller, Ivo
author_sort White, Michael
collection PubMed
description Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses.
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spelling pubmed-53802172017-04-12 Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses White, Michael Amino, Rogerio Mueller, Ivo Trends Parasitol Forum Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses. Elsevier Science 2017-04 /pmc/articles/PMC5380217/ /pubmed/28077251 http://dx.doi.org/10.1016/j.pt.2016.12.011 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Forum
White, Michael
Amino, Rogerio
Mueller, Ivo
Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses
title Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses
title_full Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses
title_fullStr Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses
title_full_unstemmed Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses
title_short Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses
title_sort theoretical implications of a pre-erythrocytic plasmodium vivax vaccine for preventing relapses
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380217/
https://www.ncbi.nlm.nih.gov/pubmed/28077251
http://dx.doi.org/10.1016/j.pt.2016.12.011
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