Cargando…

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain

Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified morphology in the postnatal brain. Microglia express all essential purinergic elements such as receptors, nucleoside transporters and ecto-enzymes, including CD39 (NTPDase1) and CD73 (5'-nucleotidase), which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matyash, Marina, Zabiegalov, Oleksandr, Wendt, Stefan, Matyash, Vitali, Kettenmann, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380357/ https://www.ncbi.nlm.nih.gov/pubmed/28376099 http://dx.doi.org/10.1371/journal.pone.0175012

Ejemplares similares

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
por: Deaglio, Silvia, et al.
Publicado: (2007)

The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation
por: Roberts, Veena, et al.
Publicado: (2014)

Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over
por: Kling, Lovis, et al.
Publicado: (2017)

Relationship between the Gene Expression of Adenosine Kinase Isoforms and the Expression of CD39 and CD73 Ectonucleotidases in Colorectal Cancer
por: Zhulai, G. A., et al.
Publicado: (2023)

Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
por: Yang, Rui, et al.
Publicado: (2020)

Skewed CD39/CD73/adenosine pathway contributes to B-cell hyperactivation and disease progression in patients with chronic hepatitis B
por: Zhou, Shuang-Nan, et al.
Publicado: (2020)

The expression of the adenosine pathway markers CD39 and CD73 in salivary gland carcinomas harbors the potential for novel immune checkpoint inhibition
por: Bauer, Arthur, et al.
Publicado: (2022)

Resident Cardiac Immune Cells and Expression of the Ectonucleotidase Enzymes CD39 and CD73 after Ischemic Injury
por: Bönner, Florian, et al.
Publicado: (2012)

Phenotypical analysis of ectoenzymes CD39/CD73 and adenosine receptor 2A in CD4(+) CD25(high)Foxp3(+) regulatory T‐cells in psoriasis
por: Han, Ling, et al.
Publicado: (2017)

Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape
por: Montalbán del Barrio, Itsaso, et al.
Publicado: (2016)

CD39/CD73 Dysregulation of Adenosine Metabolism Increases Decidual Natural Killer Cell Cytotoxicity: Implications in Unexplained Recurrent Spontaneous Abortion
por: Zhu, Jianan, et al.
Publicado: (2022)

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians
por: Crooke, Almudena, et al.
Publicado: (2017)

Monitoring and characterizing soluble and membrane-bound ectonucleotidases CD73 and CD39
por: Goueli, Said A., et al.
Publicado: (2019)

CD39 and CD73 as Promising Therapeutic Targets: What Could Be the Limitations?
por: Battastini, Ana Maria Oliveira, et al.
Publicado: (2021)

CD39/CD73/A2AR pathway and cancer immunotherapy
por: Xia, Chenglai, et al.
Publicado: (2023)

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
por: Jiang, Xuan, et al.
Publicado: (2023)

Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer
por: Gardani, Carla Fernanda Furtado, et al.
Publicado: (2023)

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
por: Krabbe, Grietje, et al.
Publicado: (2013)

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors
por: Schäkel, Laura, et al.
Publicado: (2020)

CD73-Generated Adenosine: Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth
por: Allard, Bertrand, et al.
Publicado: (2012)

High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
por: Aliagas, Elisabet, et al.
Publicado: (2014)

CD39/Adenosine Pathway Is Involved in AIDS Progression
por: Nikolova, Maria, et al.
Publicado: (2011)

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes
por: Ahmadi, Parimah, et al.
Publicado: (2020)

Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39–CD73–Adenosine and IDO Signals
por: Huang, Feng, et al.
Publicado: (2017)

Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses
por: Shevchenko, Ivan, et al.
Publicado: (2020)

Roles of the Adenosine Receptor and CD73 in the Regulatory Effect of γδ T Cells
por: Liang, Dongchun, et al.
Publicado: (2014)

The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine
por: Adamiak, Mateusz, et al.
Publicado: (2019)

Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR
por: Ploeg, Emily Maria, et al.
Publicado: (2023)

Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity
por: Hesse, Julia, et al.
Publicado: (2021)

NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine
por: Bai, Aiping, et al.
Publicado: (2015)

Helios, CD73 and CD39 Induction in Regulatory T Cells Exposed to Adipose Derived Mesenchymal Stem Cells
por: Fakhimi, Maryam, et al.
Publicado: (2020)

Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy
por: de Leve, Simone, et al.
Publicado: (2019)

A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway
por: Wurm, Melanie, et al.
Publicado: (2021)

Tumor intrinsic and extrinsic functions of CD73 and the adenosine pathway in lung cancer
por: Kowash, Ryan R., et al.
Publicado: (2023)

CD73‐generated extracellular adenosine promotes resolution of neutrophil‐mediated tissue injury and restrains metaplasia in pancreatitis
por: O'Brien, Baylee J., et al.
Publicado: (2022)

Cytokine-Induced Killer Cells Express CD39, CD38, CD203a, CD73 Ectoenzymes and P1 Adenosinergic Receptors
por: Horenstein, Alberto L., et al.
Publicado: (2018)

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis
por: Vieira, Cátia, et al.
Publicado: (2014)

CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease
por: Kudryavtsev, Igor, et al.
Publicado: (2019)

Author Correction: NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine
por: Bai, Aiping, et al.
Publicado: (2020)

IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression
por: Fang, Fengqin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u6mflor3d2olhqeusav3juq2ro