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Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients
INTRODUCTION: Although several treatment approaches have been proposed for tinnitus, there are currently no Food and Drug Administration (FDA)-approved agents available to treat this condition. In this study, we evaluated the effect of gabapentin on the sensation of subjective tinnitus in patients w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mashhad University of Medical Sciences
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380395/ https://www.ncbi.nlm.nih.gov/pubmed/28393057 |
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author | Goljanian Tabrizi, Ali Safavi Naini, Abbas Baradaran, Nima |
author_facet | Goljanian Tabrizi, Ali Safavi Naini, Abbas Baradaran, Nima |
author_sort | Goljanian Tabrizi, Ali |
collection | PubMed |
description | INTRODUCTION: Although several treatment approaches have been proposed for tinnitus, there are currently no Food and Drug Administration (FDA)-approved agents available to treat this condition. In this study, we evaluated the effect of gabapentin on the sensation of subjective tinnitus in patients with acoustic trauma referring to the ear, nose and throat (ENT) clinic of Taleghani Hospital during 2014. MATERIALS AND METHODS: In this double-blind, randomized clinical trial, 103 patients with tinnitus due to acoustic trauma who were referred to the ENT clinic of Taleghani Hospital during 2014 were randomized to the gabapentin (300 mg bid, n=55) or control (n=48) groups. The two groups were then compared before and after 6 weeks of treatment using a visual analog scale (VAS). At least a 30% reduction in VAS was considered a response to treatment. RESULTS: Differences between the two groups regarding sex, age, duration of disease, and audiometry results was not significant (P>0.05). After 6 weeks’ treatment, the VAS significantly decreased in both groups (P<0.001), but the reduction was significantly greater in the gabapentin group compared with control (P<0.001). Forty-nine patients (89%) in the gabapentin group and 28 control patients (58.3%) responded to treatment (≥30% reduction in VAS), with the difference between the two groups being statistically significant (P<0.001). CONCLUSION: We conclude that gabapentin 300 mg bid for 6 weeks is an effective treatment for acoustic tinnitus. In addition, the placebo effect in relieving tinnitus is remarkable. |
format | Online Article Text |
id | pubmed-5380395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-53803952017-04-07 Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients Goljanian Tabrizi, Ali Safavi Naini, Abbas Baradaran, Nima Iran J Otorhinolaryngol Original Article INTRODUCTION: Although several treatment approaches have been proposed for tinnitus, there are currently no Food and Drug Administration (FDA)-approved agents available to treat this condition. In this study, we evaluated the effect of gabapentin on the sensation of subjective tinnitus in patients with acoustic trauma referring to the ear, nose and throat (ENT) clinic of Taleghani Hospital during 2014. MATERIALS AND METHODS: In this double-blind, randomized clinical trial, 103 patients with tinnitus due to acoustic trauma who were referred to the ENT clinic of Taleghani Hospital during 2014 were randomized to the gabapentin (300 mg bid, n=55) or control (n=48) groups. The two groups were then compared before and after 6 weeks of treatment using a visual analog scale (VAS). At least a 30% reduction in VAS was considered a response to treatment. RESULTS: Differences between the two groups regarding sex, age, duration of disease, and audiometry results was not significant (P>0.05). After 6 weeks’ treatment, the VAS significantly decreased in both groups (P<0.001), but the reduction was significantly greater in the gabapentin group compared with control (P<0.001). Forty-nine patients (89%) in the gabapentin group and 28 control patients (58.3%) responded to treatment (≥30% reduction in VAS), with the difference between the two groups being statistically significant (P<0.001). CONCLUSION: We conclude that gabapentin 300 mg bid for 6 weeks is an effective treatment for acoustic tinnitus. In addition, the placebo effect in relieving tinnitus is remarkable. Mashhad University of Medical Sciences 2017-03 /pmc/articles/PMC5380395/ /pubmed/28393057 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Goljanian Tabrizi, Ali Safavi Naini, Abbas Baradaran, Nima Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients |
title | Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients |
title_full | Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients |
title_fullStr | Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients |
title_full_unstemmed | Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients |
title_short | Short-Term Effect of Gabapentin on Subjective Tinnitus in Acoustic Trauma Patients |
title_sort | short-term effect of gabapentin on subjective tinnitus in acoustic trauma patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380395/ https://www.ncbi.nlm.nih.gov/pubmed/28393057 |
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