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The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis

INTRODUCTION: The goal of this project was to evaluate the impact of immunoglobulin E (IgE) levels on outcomes in patients with chronic rhinosinusitis (CRS) who received maximal medical therapy (MMT). STUDY DESIGN: Prospective cohort study. METHODS: Thirty-eight patients who underwent MMT for CRS we...

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Autores principales: Lemos-Rodriguez, Ana M., Farzal, Zainab, Sreenath, Satyan B., Thorp, Brian D., Senior, Brent A., Zanation, Adam M., Ebert, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OceanSide Publications, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380453/
https://www.ncbi.nlm.nih.gov/pubmed/28381321
http://dx.doi.org/10.2500/ar.2017.8.0188
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author Lemos-Rodriguez, Ana M.
Farzal, Zainab
Sreenath, Satyan B.
Thorp, Brian D.
Senior, Brent A.
Zanation, Adam M.
Ebert, Charles S.
author_facet Lemos-Rodriguez, Ana M.
Farzal, Zainab
Sreenath, Satyan B.
Thorp, Brian D.
Senior, Brent A.
Zanation, Adam M.
Ebert, Charles S.
author_sort Lemos-Rodriguez, Ana M.
collection PubMed
description INTRODUCTION: The goal of this project was to evaluate the impact of immunoglobulin E (IgE) levels on outcomes in patients with chronic rhinosinusitis (CRS) who received maximal medical therapy (MMT). STUDY DESIGN: Prospective cohort study. METHODS: Thirty-eight patients who underwent MMT for CRS were assigned to three different cohorts based on their IgE levels: low IgE (<25 IU), moderate (>25 to <149 IU), and high (≥150 IU). The primary outcome evaluated was MMT failure with a surgical recommendation within each IgE cohort. Secondary outcomes included changes in pre- and post-MMT scores for the Rhinosinusitis Disability Index, Chronic Sinusitis Survey, and computed tomography–based Lund-Mackay evaluation. The cohorts were substratified based on the presence of nasal polyps and nasal allergies. RESULTS: No significant difference was found when MMT failure was compared between the cohorts in terms of quality of life. When substratified based on the presence of nasal polyps and nasal allergies, there was no significant difference between the cohorts. In the high-IgE cohort, all patients regardless of presence of nasal polyps and nasal allergic disease, frequently failed MMT and were recommended for surgery. CONCLUSIONS: Overall, IgE levels did not seem to have a significant effect on the quality of life or outcomes of MMT in the patients with CRS. However, the presence of nasal allergies regardless of IgE levels seemed to result in more frequent recommendations for surgery after MMT. In the patients with higher-IgE levels (≥150 IU), MMT seemed to fail at high rates with or without the presence of polyps or allergic disease.
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spelling pubmed-53804532017-04-07 The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis Lemos-Rodriguez, Ana M. Farzal, Zainab Sreenath, Satyan B. Thorp, Brian D. Senior, Brent A. Zanation, Adam M. Ebert, Charles S. Allergy Rhinol (Providence) Articles INTRODUCTION: The goal of this project was to evaluate the impact of immunoglobulin E (IgE) levels on outcomes in patients with chronic rhinosinusitis (CRS) who received maximal medical therapy (MMT). STUDY DESIGN: Prospective cohort study. METHODS: Thirty-eight patients who underwent MMT for CRS were assigned to three different cohorts based on their IgE levels: low IgE (<25 IU), moderate (>25 to <149 IU), and high (≥150 IU). The primary outcome evaluated was MMT failure with a surgical recommendation within each IgE cohort. Secondary outcomes included changes in pre- and post-MMT scores for the Rhinosinusitis Disability Index, Chronic Sinusitis Survey, and computed tomography–based Lund-Mackay evaluation. The cohorts were substratified based on the presence of nasal polyps and nasal allergies. RESULTS: No significant difference was found when MMT failure was compared between the cohorts in terms of quality of life. When substratified based on the presence of nasal polyps and nasal allergies, there was no significant difference between the cohorts. In the high-IgE cohort, all patients regardless of presence of nasal polyps and nasal allergic disease, frequently failed MMT and were recommended for surgery. CONCLUSIONS: Overall, IgE levels did not seem to have a significant effect on the quality of life or outcomes of MMT in the patients with CRS. However, the presence of nasal allergies regardless of IgE levels seemed to result in more frequent recommendations for surgery after MMT. In the patients with higher-IgE levels (≥150 IU), MMT seemed to fail at high rates with or without the presence of polyps or allergic disease. OceanSide Publications, Inc. 2017-03 /pmc/articles/PMC5380453/ /pubmed/28381321 http://dx.doi.org/10.2500/ar.2017.8.0188 Text en Copyright © 2017, OceanSide Publications, Inc., U.S.A. This work is published and licensed by OceanSide Publications, Inc. The full terms of this license are available at https://www.allergyandrhinology.com/terms and incorporate the Creative Commons License Deed: (Attribution – Non-Commercial – NoDerivs 4.0 Unported (CC BY-NC-ND 4.0). By accessing the work you hereby accept the terms. Non-commercial uses of the work are permitted without any further permission from OceanSide Publications, Inc., provided the work is properly attributed. Any use of the work other then as authorized under this license or copyright law is prohibited.
spellingShingle Articles
Lemos-Rodriguez, Ana M.
Farzal, Zainab
Sreenath, Satyan B.
Thorp, Brian D.
Senior, Brent A.
Zanation, Adam M.
Ebert, Charles S.
The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis
title The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis
title_full The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis
title_fullStr The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis
title_full_unstemmed The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis
title_short The impact of total immunoglobulin E levels on outcomes of maximal medical therapy for chronic rhinosinusitis
title_sort impact of total immunoglobulin e levels on outcomes of maximal medical therapy for chronic rhinosinusitis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380453/
https://www.ncbi.nlm.nih.gov/pubmed/28381321
http://dx.doi.org/10.2500/ar.2017.8.0188
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