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Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media

The uptake of circulating macromolecules by the arterial intima is thought to be a key step in atherogenesis. Such transport is dominantly advective, so elucidating the mechanisms of water transport is important. The relation between vasoactive agents and water transport in the arterial wall is inco...

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Autores principales: Chooi, K.Y., Comerford, A., Sherwin, S.J., Weinberg, P.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380660/
https://www.ncbi.nlm.nih.gov/pubmed/28256247
http://dx.doi.org/10.1016/j.jbiomech.2017.01.027
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author Chooi, K.Y.
Comerford, A.
Sherwin, S.J.
Weinberg, P.D.
author_facet Chooi, K.Y.
Comerford, A.
Sherwin, S.J.
Weinberg, P.D.
author_sort Chooi, K.Y.
collection PubMed
description The uptake of circulating macromolecules by the arterial intima is thought to be a key step in atherogenesis. Such transport is dominantly advective, so elucidating the mechanisms of water transport is important. The relation between vasoactive agents and water transport in the arterial wall is incompletely understood. Here we applied our recently-developed combination of computational and experimental methods to investigate the effects of noradrenaline (NA) on hydraulic conductance of the wall ([Formula: see text]), medial extracellular matrix volume fraction ([Formula: see text]) and medial permeability ([Formula: see text]) in the rat abdominal aorta. Experimentally, we found that physiological NA concentrations were sufficient to induce SMC contraction and produced significant decreases in [Formula: see text] and increases in [Formula: see text]. Simulation results based on 3D confocal images of the extracellular volume showed a corresponding increase in [Formula: see text] , attributed to the opening of the ECM. Conversion of permeabilities to layer-specific resistances revealed that although the total wall resistance increased, medial resistance decreased, suggesting an increase in intimal resistance upon application of NA.
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spelling pubmed-53806602017-04-12 Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media Chooi, K.Y. Comerford, A. Sherwin, S.J. Weinberg, P.D. J Biomech Article The uptake of circulating macromolecules by the arterial intima is thought to be a key step in atherogenesis. Such transport is dominantly advective, so elucidating the mechanisms of water transport is important. The relation between vasoactive agents and water transport in the arterial wall is incompletely understood. Here we applied our recently-developed combination of computational and experimental methods to investigate the effects of noradrenaline (NA) on hydraulic conductance of the wall ([Formula: see text]), medial extracellular matrix volume fraction ([Formula: see text]) and medial permeability ([Formula: see text]) in the rat abdominal aorta. Experimentally, we found that physiological NA concentrations were sufficient to induce SMC contraction and produced significant decreases in [Formula: see text] and increases in [Formula: see text]. Simulation results based on 3D confocal images of the extracellular volume showed a corresponding increase in [Formula: see text] , attributed to the opening of the ECM. Conversion of permeabilities to layer-specific resistances revealed that although the total wall resistance increased, medial resistance decreased, suggesting an increase in intimal resistance upon application of NA. Elsevier Science 2017-03-21 /pmc/articles/PMC5380660/ /pubmed/28256247 http://dx.doi.org/10.1016/j.jbiomech.2017.01.027 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chooi, K.Y.
Comerford, A.
Sherwin, S.J.
Weinberg, P.D.
Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
title Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
title_full Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
title_fullStr Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
title_full_unstemmed Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
title_short Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
title_sort noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380660/
https://www.ncbi.nlm.nih.gov/pubmed/28256247
http://dx.doi.org/10.1016/j.jbiomech.2017.01.027
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