A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

BACKGROUND: Filaggrin, which is encoded by the filaggrin gene (FLG), is an important component of the skin's barrier to the external environment, and genetic defects in FLG strongly associate with atopic dermatitis (AD). However, not all patients with AD have FLG mutations. OBJECTIVE: We hypoth...

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Detalles Bibliográficos
Autores principales: Naeem, Aishath S., Tommasi, Cristina, Cole, Christian, Brown, Stuart J., Zhu, Yanan, Way, Benjamin, Willis Owen, Saffron A.G., Moffatt, Miriam, Cookson, William O., Harper, John I., Di, Wei-Li, Brown, Sara J., Reinheckel, Thomas, O'Shaughnessy, Ryan F.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2017
Materias:
Atopic Dermatitis and Skin Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380661/
https://www.ncbi.nlm.nih.gov/pubmed/27913303
http://dx.doi.org/10.1016/j.jaci.2016.09.052

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