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Green Toxicology: a strategy for sustainable chemical and material development

Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of “Green Chemistry” and “Green Engineering”, “Green Toxicology” aims to...

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Autores principales: Crawford, Sarah E., Hartung, Thomas, Hollert, Henner, Mathes, Björn, van Ravenzwaay, Bennard, Steger-Hartmann, Thomas, Studer, Christoph, Krug, Harald F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380705/
https://www.ncbi.nlm.nih.gov/pubmed/28435767
http://dx.doi.org/10.1186/s12302-017-0115-z
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author Crawford, Sarah E.
Hartung, Thomas
Hollert, Henner
Mathes, Björn
van Ravenzwaay, Bennard
Steger-Hartmann, Thomas
Studer, Christoph
Krug, Harald F.
author_facet Crawford, Sarah E.
Hartung, Thomas
Hollert, Henner
Mathes, Björn
van Ravenzwaay, Bennard
Steger-Hartmann, Thomas
Studer, Christoph
Krug, Harald F.
author_sort Crawford, Sarah E.
collection PubMed
description Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of “Green Chemistry” and “Green Engineering”, “Green Toxicology” aims to shape future manufacturing processes and safe synthesis of chemicals in terms of environmental and human health impacts. Being an integral part of Green Chemistry, the principles of Green Toxicology amplify the role of health-related aspects for the benefit of consumers and the environment, in addition to being economical for manufacturing companies. Due to the costly development and preparation of new materials and chemicals for market entry, it is no longer practical to ignore the safety and environmental status of new products during product development stages. However, this is only possible if toxicologists and chemists work together early on in the development of materials and chemicals to utilize safe design strategies and innovative in vitro and in silico tools. This paper discusses some of the most relevant aspects, advances and limitations of the emergence of Green Toxicology from the perspective of different industry and research groups. The integration of new testing methods and strategies in product development, testing and regulation stages are presented with examples of the application of in silico, omics and in vitro methods. Other tools for Green Toxicology, including the reduction of animal testing, alternative test methods, and read-across approaches are also discussed.
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spelling pubmed-53807052017-04-20 Green Toxicology: a strategy for sustainable chemical and material development Crawford, Sarah E. Hartung, Thomas Hollert, Henner Mathes, Björn van Ravenzwaay, Bennard Steger-Hartmann, Thomas Studer, Christoph Krug, Harald F. Environ Sci Eur Commentary Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of “Green Chemistry” and “Green Engineering”, “Green Toxicology” aims to shape future manufacturing processes and safe synthesis of chemicals in terms of environmental and human health impacts. Being an integral part of Green Chemistry, the principles of Green Toxicology amplify the role of health-related aspects for the benefit of consumers and the environment, in addition to being economical for manufacturing companies. Due to the costly development and preparation of new materials and chemicals for market entry, it is no longer practical to ignore the safety and environmental status of new products during product development stages. However, this is only possible if toxicologists and chemists work together early on in the development of materials and chemicals to utilize safe design strategies and innovative in vitro and in silico tools. This paper discusses some of the most relevant aspects, advances and limitations of the emergence of Green Toxicology from the perspective of different industry and research groups. The integration of new testing methods and strategies in product development, testing and regulation stages are presented with examples of the application of in silico, omics and in vitro methods. Other tools for Green Toxicology, including the reduction of animal testing, alternative test methods, and read-across approaches are also discussed. Springer Berlin Heidelberg 2017-04-04 2017 /pmc/articles/PMC5380705/ /pubmed/28435767 http://dx.doi.org/10.1186/s12302-017-0115-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Commentary
Crawford, Sarah E.
Hartung, Thomas
Hollert, Henner
Mathes, Björn
van Ravenzwaay, Bennard
Steger-Hartmann, Thomas
Studer, Christoph
Krug, Harald F.
Green Toxicology: a strategy for sustainable chemical and material development
title Green Toxicology: a strategy for sustainable chemical and material development
title_full Green Toxicology: a strategy for sustainable chemical and material development
title_fullStr Green Toxicology: a strategy for sustainable chemical and material development
title_full_unstemmed Green Toxicology: a strategy for sustainable chemical and material development
title_short Green Toxicology: a strategy for sustainable chemical and material development
title_sort green toxicology: a strategy for sustainable chemical and material development
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380705/
https://www.ncbi.nlm.nih.gov/pubmed/28435767
http://dx.doi.org/10.1186/s12302-017-0115-z
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